The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10209697" target="_blank" >RIV/00216208:11130/13:10209697 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/13:00397685
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.biochi.2013.08.004" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2013.08.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biochi.2013.08.004" target="_blank" >10.1016/j.biochi.2013.08.004</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
Popis výsledku v původním jazyce
Diseases of the central nervous system still remain among the most challenging pathologies known to mankind, having no or limited therapeutic possibilities and a very pessimistic prognosis. Advances in stem cell biology in the last decade have shown thatstem cells might provide an inexhaustible source of neurons and glia as well as exerting a neuroprotective effect on the host tissue, thus opening new horizons for tissue engineering and regenerative medicine. Here, we discuss the progress made in the cell-based therapy of spinal cord injury. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). We then review the latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs. We also attempt to correlate the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI. Finally, we discuss the results from preclinical and clinical trials invol
Název v anglickém jazyce
The role of mesenchymal stromal cells in spinal cord injury, regenerative medicine and possible clinical applications
Popis výsledku anglicky
Diseases of the central nervous system still remain among the most challenging pathologies known to mankind, having no or limited therapeutic possibilities and a very pessimistic prognosis. Advances in stem cell biology in the last decade have shown thatstem cells might provide an inexhaustible source of neurons and glia as well as exerting a neuroprotective effect on the host tissue, thus opening new horizons for tissue engineering and regenerative medicine. Here, we discuss the progress made in the cell-based therapy of spinal cord injury. An emphasis has been placed on the application of adult mesenchymal stromal cells (MSCs). We then review the latest and most significant results from in vitro and in vivo research focusing on the regenerative/neuroprotective properties of MSCs. We also attempt to correlate the effect of MSCs with the pathological events that are taking place in the nervous tissue after SCI. Finally, we discuss the results from preclinical and clinical trials invol
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biochimie
ISSN
0300-9084
e-ISSN
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Svazek periodika
95
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
FR - Francouzská republika
Počet stran výsledku
14
Strana od-do
2257-2270
Kód UT WoS článku
000327805400008
EID výsledku v databázi Scopus
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