Proteomic techniques for characterisation of mesenchymal stem cell secretome.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F13%3A00420728" target="_blank" >RIV/67985904:_____/13:00420728 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biochi.2013.07.015" target="_blank" >http://dx.doi.org/10.1016/j.biochi.2013.07.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biochi.2013.07.015" target="_blank" >10.1016/j.biochi.2013.07.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Proteomic techniques for characterisation of mesenchymal stem cell secretome.

Popis výsledku v původním jazyce

Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human regenerative medicine due to their ability to migrate to sites of injury, capability to suppress immune response and accessibility in large amount from patient's own bone marrow or fat tissue. It has been increasingly observed that the transplanted MSCs did not necessarily engraft and differentiate at the site of injury but might exert their therapeutic effects through secreted trophic signals. The MSCs secrete a variety of autocrine/paracrine factors, called secretome, that support regenerative processes in the damaged tissue, induce angiogenesis, protect cells from apoptotic cell death and modulate immune system. The cell culture medium conditioned by MSCs or osteogenic, chondrogenic as well as adipogenic precursors derived from MSCs has become a subject of intensive proteomic profiling in the search for and identification of released factors and microvesicles that might be applicable in regener

Název v anglickém jazyce

Proteomic techniques for characterisation of mesenchymal stem cell secretome.

Popis výsledku anglicky

Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human regenerative medicine due to their ability to migrate to sites of injury, capability to suppress immune response and accessibility in large amount from patient's own bone marrow or fat tissue. It has been increasingly observed that the transplanted MSCs did not necessarily engraft and differentiate at the site of injury but might exert their therapeutic effects through secreted trophic signals. The MSCs secrete a variety of autocrine/paracrine factors, called secretome, that support regenerative processes in the damaged tissue, induce angiogenesis, protect cells from apoptotic cell death and modulate immune system. The cell culture medium conditioned by MSCs or osteogenic, chondrogenic as well as adipogenic precursors derived from MSCs has become a subject of intensive proteomic profiling in the search for and identification of released factors and microvesicles that might be applicable in regener

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochimie

ISSN

0300-9084

e-ISSN

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Svazek periodika

95

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

16

Strana od-do

2196-2211

Kód UT WoS článku

000327805400002

EID výsledku v databázi Scopus

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