The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F13%3A10210476" target="_blank" >RIV/00216208:11130/13:10210476 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/13:10210476
Výsledek na webu
<a href="http://www.ibimapublishing.com/journals/IMMU/2013/119348/119348.pdf" target="_blank" >http://www.ibimapublishing.com/journals/IMMU/2013/119348/119348.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5171/2013.119348" target="_blank" >10.5171/2013.119348</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
Popis výsledku v původním jazyce
The article gives overview of both surface and intracellular markers present on T regulatory lymphocytes. Regulatory T cells (Tregs) play a proncipal role in immune reactions including autoimmunity, transplantation tolerance, anti-infectious immunity andcancer. Today the most widely accepted phenotype for Tregs is the coexpression of CD4, CD25 and FoxP3. But FoxP3 is an intracellular molecule, detection of which requires, fixation and permeabilization of cells and the fixed cells cannot be used in studies of Treg function. Moreover intracellular FofP3 staining is hardly usable on a daily clinical routine basis. Therefore several attempts have been characterize TRgs according their surface molecules. The particular molecules like CD25, CD127, CD26, CD39, CD45RA, CD49d, CD101, CD194 are described and their significance for distinguishing T regulatory lymphocytes from other T cells is discussed. Recently described surface molecule CD26 is another negative marker which seems to improve ou
Název v anglickém jazyce
The Phenotypic Markers of CD4+CD25+ T Regulatory Lymphocytes
Popis výsledku anglicky
The article gives overview of both surface and intracellular markers present on T regulatory lymphocytes. Regulatory T cells (Tregs) play a proncipal role in immune reactions including autoimmunity, transplantation tolerance, anti-infectious immunity andcancer. Today the most widely accepted phenotype for Tregs is the coexpression of CD4, CD25 and FoxP3. But FoxP3 is an intracellular molecule, detection of which requires, fixation and permeabilization of cells and the fixed cells cannot be used in studies of Treg function. Moreover intracellular FofP3 staining is hardly usable on a daily clinical routine basis. Therefore several attempts have been characterize TRgs according their surface molecules. The particular molecules like CD25, CD127, CD26, CD39, CD45RA, CD49d, CD101, CD194 are described and their significance for distinguishing T regulatory lymphocytes from other T cells is discussed. Recently described surface molecule CD26 is another negative marker which seems to improve ou
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Research in Immunology: An International Journal
ISSN
2331-7299
e-ISSN
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Svazek periodika
2013
Číslo periodika v rámci svazku
neuveden
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
14
Strana od-do
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Kód UT WoS článku
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EID výsledku v databázi Scopus
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