Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F14%3A10293064" target="_blank" >RIV/00216208:11130/14:10293064 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/14:00435640

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s13028-014-0072-0" target="_blank" >http://dx.doi.org/10.1186/s13028-014-0072-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13028-014-0072-0" target="_blank" >10.1186/s13028-014-0072-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia

Popis výsledku v původním jazyce

Background: Hypoxia results in an imbalance between oxygen supply and oxygen consumption. This study utilized microdialysis to monitor changes in the energy-related metabolites lactate, pyruvate and glucose in rat muscle before, during and after 30 minutes of transient global hypoxia. Hypoxia was induced in anaesthetised rats by reducing inspired oxygen to 6% O-2 in nitrogen. Results: Basal values for lactate, the lactate/pyruvate ratio and glucose were 0.72 +/- 0.04 mmol/l, 10.03 +/- 1.16 and 3.55 +/-0.19 mmol/l (n = 10), respectively. Significant increases in lactate and the lactate/pyruvate ratio were found in the muscle after the induction of hypoxia. Maximum values of 2.26 +/- 0.37 mmol/l for lactate were reached during early reperfusion, while the lactate/pyruvate ratio reached maximum values of 35.84 +/- 7.81 at the end of hypoxia. Following recovery to ventilation with air, extracellular lactate levels and the lactate/pyruvate ratio returned to control levels within 30-40 minu

Název v anglickém jazyce

Interstitial lactate, lactate/pyruvate and glucose in rat muscle before, during and in the recovery from global hypoxia

Popis výsledku anglicky

Background: Hypoxia results in an imbalance between oxygen supply and oxygen consumption. This study utilized microdialysis to monitor changes in the energy-related metabolites lactate, pyruvate and glucose in rat muscle before, during and after 30 minutes of transient global hypoxia. Hypoxia was induced in anaesthetised rats by reducing inspired oxygen to 6% O-2 in nitrogen. Results: Basal values for lactate, the lactate/pyruvate ratio and glucose were 0.72 +/- 0.04 mmol/l, 10.03 +/- 1.16 and 3.55 +/-0.19 mmol/l (n = 10), respectively. Significant increases in lactate and the lactate/pyruvate ratio were found in the muscle after the induction of hypoxia. Maximum values of 2.26 +/- 0.37 mmol/l for lactate were reached during early reperfusion, while the lactate/pyruvate ratio reached maximum values of 35.84 +/- 7.81 at the end of hypoxia. Following recovery to ventilation with air, extracellular lactate levels and the lactate/pyruvate ratio returned to control levels within 30-40 minu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Veterinaria Scandinavica

ISSN

0044-605X

e-ISSN

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Svazek periodika

56

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000344889000001

EID výsledku v databázi Scopus

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