Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10294521" target="_blank" >RIV/00216208:11130/15:10294521 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10294521

Výsledek na webu

<a href="http://dx.doi.org/10.3324/haematol.2014.107706" target="_blank" >http://dx.doi.org/10.3324/haematol.2014.107706</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2014.107706" target="_blank" >10.3324/haematol.2014.107706</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood

Popis výsledku v původním jazyce

Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia fromthe immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone marrow has been shown to be a valuable diagnostic tool in differentiating myelodysplastic syndrome from non-clonal cytopenias in adults. Here, we performed the first comprehensive flow cytometric analysis of immature myeloid, lymphoid cells and erythroid cells, and granulocytes, monocytes, and lymphoid cells in bone marrow obtained from a large prospective cohort of 81 children with refractory cytopenia. Children with refractory cyotopenia had a strongly reduced myeloid compartment, but not as severe as children with aplastic anemia. Furthermore, the number of flow cytometric abnormalities was sign

Název v anglickém jazyce

Bone marrow immunophenotyping by flow cytometry in refractory cytopenia of childhood

Popis výsledku anglicky

Refractory cytopenia of childhood is the most common type of childhood myelodysplastic syndrome. Because the majority of children with refractory cytopenia have a normal karyotype and a hypocellular bone marrow, differentiating refractory cytopenia fromthe immune-mediated bone marrow failure syndrome (very) severe aplastic anemia can be challenging. Flow cytometric immunophenotyping of bone marrow has been shown to be a valuable diagnostic tool in differentiating myelodysplastic syndrome from non-clonal cytopenias in adults. Here, we performed the first comprehensive flow cytometric analysis of immature myeloid, lymphoid cells and erythroid cells, and granulocytes, monocytes, and lymphoid cells in bone marrow obtained from a large prospective cohort of 81 children with refractory cytopenia. Children with refractory cyotopenia had a strongly reduced myeloid compartment, but not as severe as children with aplastic anemia. Furthermore, the number of flow cytometric abnormalities was sign

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14534" target="_blank" >NT14534: Úloha průtokové cytometrie a nových molekulárních metod v diagnostice dětských forem selhání kostní dřeně</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Haematologica

ISSN

0390-6078

e-ISSN

—

Svazek periodika

100

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

9

Strana od-do

315-323

Kód UT WoS článku

000351279900020

EID výsledku v databázi Scopus

2-s2.0-84924709594