Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315341" target="_blank" >RIV/00216208:11130/15:10315341 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10315341

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clim.2015.08.013" target="_blank" >http://dx.doi.org/10.1016/j.clim.2015.08.013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clim.2015.08.013" target="_blank" >10.1016/j.clim.2015.08.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients

Popis výsledku v původním jazyce

Purpose: Patients with DiGeorge syndrome suffer from T-Iymphopenia.T-cells are important for the maturation and regulation of B-cell function. Our aim was to characterize the B-cell compartment in DiGeorge syndrome patients. Methods: B-cell subset phenotypization using flow cytometry. Serum BAFF (B-cell activating factor) and serum anti-alpha-galactosyl IgM measurement using ELISA. Serum IgG measurement using nephelometry. Results: We observed a significantly increased number of naive B-cells and decreased number of switched memory B-cells in DiGeorge patients. Furthermore, we observed increased BAFF levels and a trend toward hypergammaglobulinemia later in life. Surprisingly, we detected a decrease in marginal zone-like (MZ-like) Bcells and natural antibodies in DiGeorge patients. Conclusion: The maturation of B-cells is impaired in DiGeorge patients, with high naive and low switched memory B-cell numbers being observed. There is a clear trend toward hypergammaglobulinemia later in li

Název v anglickém jazyce

Low marginal zone-like B lymphocytes and natural antibodies characterize skewed B-lymphocyte subpopulations in del22q11 DiGeorge patients

Popis výsledku anglicky

Purpose: Patients with DiGeorge syndrome suffer from T-Iymphopenia.T-cells are important for the maturation and regulation of B-cell function. Our aim was to characterize the B-cell compartment in DiGeorge syndrome patients. Methods: B-cell subset phenotypization using flow cytometry. Serum BAFF (B-cell activating factor) and serum anti-alpha-galactosyl IgM measurement using ELISA. Serum IgG measurement using nephelometry. Results: We observed a significantly increased number of naive B-cells and decreased number of switched memory B-cells in DiGeorge patients. Furthermore, we observed increased BAFF levels and a trend toward hypergammaglobulinemia later in life. Surprisingly, we detected a decrease in marginal zone-like (MZ-like) Bcells and natural antibodies in DiGeorge patients. Conclusion: The maturation of B-cells is impaired in DiGeorge patients, with high naive and low switched memory B-cell numbers being observed. There is a clear trend toward hypergammaglobulinemia later in li

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT13287" target="_blank" >NT13287: Regulace imunity u syndromu DiGeorge.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Immunology

ISSN

1521-6616

e-ISSN

—

Svazek periodika

161

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

144-149

Kód UT WoS článku

000365831600012

EID výsledku v databázi Scopus

2-s2.0-84942517704