Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10295372" target="_blank" >RIV/00216208:11150/15:10295372 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/15:10295372

Výsledek na webu

<a href="http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010025.pdf" target="_blank" >http://actamedica.lfhk.cuni.cz/media/pdf/am_2015058010025.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/18059694.2015.88" target="_blank" >10.14712/18059694.2015.88</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR

Popis výsledku v původním jazyce

The presence of a broad spectrum of autoantibodies in Sjögren's syndrome (SjS) patients in the result of abnormal B-cell regulation that can be at least partially explained by abnormal BAFF/BAFFR regulation. The objective of this study was to determine both membrane and intracellular expression of BAFF/BAFFR in monocytes and B-cells in peripheral blood of 19 primary Sjögren's syndrome patients and 20 healthy controls using flow cytometry. We also measured sBAFF in serum. Compared to healthy controls, both surface and intracellular expression of BAFF was significantly increased in monocytes and B-cells of SjS patients. Also serum sBAFF level was elevated. Expression of BAFFR on B-cells of SjS patients was surprisingly decreased, but there was no clear increase or decrease within monocytes. Our results indicate that activated monocytes communicate with B-cells via BAFF and BAFFR, so that B-cells are stimulated, but BAFF is also produced to stimulate cells in autocrine way. The decrease o

Název v anglickém jazyce

Increase of intracellular BAFF in B cells of Sjögren's patients is not affected by decrease of BAFFR

Popis výsledku anglicky

The presence of a broad spectrum of autoantibodies in Sjögren's syndrome (SjS) patients in the result of abnormal B-cell regulation that can be at least partially explained by abnormal BAFF/BAFFR regulation. The objective of this study was to determine both membrane and intracellular expression of BAFF/BAFFR in monocytes and B-cells in peripheral blood of 19 primary Sjögren's syndrome patients and 20 healthy controls using flow cytometry. We also measured sBAFF in serum. Compared to healthy controls, both surface and intracellular expression of BAFF was significantly increased in monocytes and B-cells of SjS patients. Also serum sBAFF level was elevated. Expression of BAFFR on B-cells of SjS patients was surprisingly decreased, but there was no clear increase or decrease within monocytes. Our results indicate that activated monocytes communicate with B-cells via BAFF and BAFFR, so that B-cells are stimulated, but BAFF is also produced to stimulate cells in autocrine way. The decrease o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Medica (Hradec Králové)

ISSN

1211-4286

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

25-31

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-84953410710