Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10315843" target="_blank" >RIV/00216208:11130/15:10315843 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/15:10315843
Výsledek na webu
<a href="http://dx.doi.org/10.3109/00365513.2015.1031694" target="_blank" >http://dx.doi.org/10.3109/00365513.2015.1031694</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00365513.2015.1031694" target="_blank" >10.3109/00365513.2015.1031694</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
Popis výsledku v původním jazyce
Background. Hypothermic coagulopathy is very challenging in bleeding trauma patients. Therefore, we decided to evaluate the efficacy of fibrinogen and prothrombin complex in 30 degrees C hypothermia in vitro to investigate if higher levels of fibrinogenand prothrombin complex concentrate can compensate for the hypothermic effect on coagulation as measured by thromboelastometry/thromboelastography. Methods. Blood samples were obtained from 12 healthy volunteers (six men and six women) in our study. Measurements were performed at 37 degrees C and 30 degrees C simultaneously, then at 30 degrees C with adding fibrinogen and prothrombin complex and in the last step samples with added coagulation factors were warmed back to 37 degrees C. Results. We found that 30 degrees C hypothermic coagulopathy can be detected both by thromboelastometry and thromboelastography. Hypothermic coagulopathy can be restored by fibrinogen to the point where the results do not significantly differ from 37 degree
Název v anglickém jazyce
Evaluation of fibrinogen concentrates and prothrombin complex concentrates on coagulation changes in a hypothermic in vitro model using thromboelastometry and thromboelastography
Popis výsledku anglicky
Background. Hypothermic coagulopathy is very challenging in bleeding trauma patients. Therefore, we decided to evaluate the efficacy of fibrinogen and prothrombin complex in 30 degrees C hypothermia in vitro to investigate if higher levels of fibrinogenand prothrombin complex concentrate can compensate for the hypothermic effect on coagulation as measured by thromboelastometry/thromboelastography. Methods. Blood samples were obtained from 12 healthy volunteers (six men and six women) in our study. Measurements were performed at 37 degrees C and 30 degrees C simultaneously, then at 30 degrees C with adding fibrinogen and prothrombin complex and in the last step samples with added coagulation factors were warmed back to 37 degrees C. Results. We found that 30 degrees C hypothermic coagulopathy can be detected both by thromboelastometry and thromboelastography. Hypothermic coagulopathy can be restored by fibrinogen to the point where the results do not significantly differ from 37 degree
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FP - Ostatní lékařské obory
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Scandinavian Journal of Clinical and Laboratory Investigation
ISSN
0036-5513
e-ISSN
—
Svazek periodika
75
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
NO - Norské království
Počet stran výsledku
8
Strana od-do
407-414
Kód UT WoS článku
000360177600009
EID výsledku v databázi Scopus
2-s2.0-84933503106