Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F15%3A10316015" target="_blank" >RIV/00216208:11130/15:10316015 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/15:10316015 RIV/00216224:14310/15:00087444

Výsledek na webu

<a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >http://dx.doi.org/10.1089/mdr.2014.0276</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/mdr.2014.0276" target="_blank" >10.1089/mdr.2014.0276</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment

Popis výsledku v původním jazyce

Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolatesfrom 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLSB) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLSB target site. The emergence ofMLSB resistance and mutations conferring resistance to MLSB antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneou

Název v anglickém jazyce

Characterization of Staphylococcus aureus Strains Isolated from Czech Cystic Fibrosis Patients: High Rate of Ribosomal Mutation Conferring Resistance to MLSB Antibiotics as a Result of Long-Term and Low-Dose Azithromycin Treatment

Popis výsledku anglicky

Staphylococcus aureus is one of the most frequent pathogens infecting the respiratory tract of patients with cystic fibrosis (CF). This study was the first to examine S. aureus isolates from CF patients in the Czech Republic. Among 100 S. aureus isolatesfrom 92 of 107 observed patients, we found a high prevalence of resistance to macrolide-lincosamide-streptogramin B (MLSB) antibiotics (56%). More than half of the resistant strains (29 of 56) carried a mutation in the MLSB target site. The emergence ofMLSB resistance and mutations conferring resistance to MLSB antibiotics was associated with azithromycin treatment (p=0.000000184 and p=0.000681, respectively). Methicillin resistance was only detected in 3% of isolates and the rate of resistance to other antibiotics did not exceed 12%. The prevalence of small-colony variant (SCV) strains was relatively low (9%) and eight of nine isolates with the SCV phenotype were thymidine dependent. The study population of S. aureus was heterogeneou

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT12395" target="_blank" >NT12395: Molekulární průkaz a analýza invazivních kmenů small colony variants (SCV) a rezistentních kmenů S. aureus od pacientů s cystickou fibrózou</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Microbial Drug Resistance

ISSN

1076-6294

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

416-423

Kód UT WoS článku

000363947200008

EID výsledku v databázi Scopus

2-s2.0-84937784708