Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373722" target="_blank" >RIV/00216208:11130/17:10373722 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373722

Výsledek na webu

<a href="https://doi.org/10.1007/s00431-017-2988-7" target="_blank" >https://doi.org/10.1007/s00431-017-2988-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00431-017-2988-7" target="_blank" >10.1007/s00431-017-2988-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures

Popis výsledku v původním jazyce

Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess vertebral fracture (VF) rate in children and adolescents with IBD. Seventy patients with IBD with a median age of 13.8 years were included. The BMD and geometric parameters of the non-dominant tibia were assessed using pQCT. Dynamic muscle functions were evaluated using jumping mechanography. VFs were assessed according to the semiquantitative standardized method by Genant. The muscle functions adjusted for the patients&apos; weight did not differ from the reference population. A low trabecular BMD (Z-score - 1.6; p &lt; 0.001) and cortical thickness (Z-score - 0.7; p &lt; 0.001) were found in children and adolescents with IBD. Conversely, an increased cortical BMD (Z-score 1.1; p &lt; 0.001) was noted. No significant association was found between the 25-OHD serum levels and the bone or muscle measurements. One patient with asymptomatic VF was identified. Conclusion: IBD in childhood or adolescents affects bones but not muscles. Bone changes are independent of the 25-OHD serum level. A thoracolumbar spine X-ray should not be routinely recommended in children with IBD.

Název v anglickém jazyce

Musculoskeletal system in children and adolescents with inflammatory bowel disease: normal muscle force, decreased trabecular bone mineral density and low prevalence of vertebral fractures

Popis výsledku anglicky

Low bone mineral density (BMD) and an increased fracture incidence are two extraintestinal complications associated with inflammatory bowel disease (IBD). We aimed to evaluate musculoskeletal traits and assess vertebral fracture (VF) rate in children and adolescents with IBD. Seventy patients with IBD with a median age of 13.8 years were included. The BMD and geometric parameters of the non-dominant tibia were assessed using pQCT. Dynamic muscle functions were evaluated using jumping mechanography. VFs were assessed according to the semiquantitative standardized method by Genant. The muscle functions adjusted for the patients&apos; weight did not differ from the reference population. A low trabecular BMD (Z-score - 1.6; p &lt; 0.001) and cortical thickness (Z-score - 0.7; p &lt; 0.001) were found in children and adolescents with IBD. Conversely, an increased cortical BMD (Z-score 1.1; p &lt; 0.001) was noted. No significant association was found between the 25-OHD serum levels and the bone or muscle measurements. One patient with asymptomatic VF was identified. Conclusion: IBD in childhood or adolescents affects bones but not muscles. Bone changes are independent of the 25-OHD serum level. A thoracolumbar spine X-ray should not be routinely recommended in children with IBD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pediatrics

ISSN

0340-6199

e-ISSN

—

Svazek periodika

176

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

1355-1363

Kód UT WoS článku

000410752800008

EID výsledku v databázi Scopus

2-s2.0-85028333344