Muscle functions and bone strength are impaired in adolescents with type 1 diabetes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375420" target="_blank" >RIV/00216208:11130/18:10375420 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11320/18:10375420 RIV/00064203:_____/18:10375420

Výsledek na webu

<a href="https://doi.org/10.1016/j.bone.2017.10.005" target="_blank" >https://doi.org/10.1016/j.bone.2017.10.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bone.2017.10.005" target="_blank" >10.1016/j.bone.2017.10.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Muscle functions and bone strength are impaired in adolescents with type 1 diabetes

Popis výsledku v původním jazyce

Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. Methods: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2 +/- 1.2 years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease (&lt;6 years and &gt;9 years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography (pQCT). Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5 years. Results: Relative muscle power (P-max/mass) and force (F-max/body weight) were significantly decreased in T1D subjects (mean Z-scores -0.4 +/- 1.0; p &lt; 0.001, and -03 +/- 1.1; p &lt; 0.01, respectively). The duration of T1D negatively affected Pmax/mass (p &lt; 0.01) but not Fmax/body weight (p = 0.54). Patients with T1D had also decreased trabecular BMD, the Strength-Strain Index and cortical thickness (mean Z-scores -0.8 +/- 1.3; -0.5 +/- 0.8 and -1.1 0.8, respectively, p &lt; 0.001 for all) whereas cortical BMD was increased when compared to controls (Z-score 12 +/- 0.90, p &lt; 0.001). No association was observed between the HbA1c and 25-hydroxyvitamin D levels and bone or muscle parameters. Conclusion: T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients.

Název v anglickém jazyce

Muscle functions and bone strength are impaired in adolescents with type 1 diabetes

Popis výsledku anglicky

Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system. Methods: Ninety-five children and adolescents (59 boys and 36 girls, mean age 16.2 +/- 1.2 years) with T1D were included in this cross-sectional study. Study participants were divided into two groups according to the duration of the disease (&lt;6 years and &gt;9 years, respectively). Volumetric BMD of the non-dominant tibia was assessed using peripheral quantitative computed tomography (pQCT). Dynamic muscle function was evaluated using jumping mechanography. Gender- and height-specific Z-scores were calculated using published reference data. HbA1c was evaluated retrospectively as an average over the past 5 years. Results: Relative muscle power (P-max/mass) and force (F-max/body weight) were significantly decreased in T1D subjects (mean Z-scores -0.4 +/- 1.0; p &lt; 0.001, and -03 +/- 1.1; p &lt; 0.01, respectively). The duration of T1D negatively affected Pmax/mass (p &lt; 0.01) but not Fmax/body weight (p = 0.54). Patients with T1D had also decreased trabecular BMD, the Strength-Strain Index and cortical thickness (mean Z-scores -0.8 +/- 1.3; -0.5 +/- 0.8 and -1.1 0.8, respectively, p &lt; 0.001 for all) whereas cortical BMD was increased when compared to controls (Z-score 12 +/- 0.90, p &lt; 0.001). No association was observed between the HbA1c and 25-hydroxyvitamin D levels and bone or muscle parameters. Conclusion: T1D influences the musculoskeletal system in adolescence. Decreased muscle function could contribute to the osteoporosis reported in adult diabetic patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bone

ISSN

8756-3282

e-ISSN

—

Svazek periodika

106

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

22-27

Kód UT WoS článku

000417552200003

EID výsledku v databázi Scopus

2-s2.0-85030988212