KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373785" target="_blank" >RIV/00216208:11130/17:10373785 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373785

Výsledek na webu

<a href="https://doi.org/10.1016/j.diabres.2017.05.018" target="_blank" >https://doi.org/10.1016/j.diabres.2017.05.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diabres.2017.05.018" target="_blank" >10.1016/j.diabres.2017.05.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors

Popis výsledku v původním jazyce

Aims: Only a few gene variants were associated with the response to dipeptidylpeptidase-4 inhibitors (DPP4I). KCNQ1 gene variants were previously related both to type 2 diabetes (T2D) and incretin effect. We hypothesized that T2D related KCNQ1 variants would be associated with smaller glucose-lowering effect of DDP4I. Methods: We performed a retrospective study in 137 Caucasian subjects with T2D who were followed for 6 months after initiation of DPP4I treatment. Genotyping for KCNQ1 rs163184 and rs151290 was performed using PCR-HRMA and PCR-RFLP methods, respectively. The main clinical outcome was reduction in HbA1c (DHbA1c) after 6-month DPP4I treatment. Results: KCNQ1 rs163184 T &gt; G variant was associated with the response to DPP4I treatment in genetic additive model (beta = -0.30, p = 0.022). For each G allele in the rs163184 genotype, we observed a 0.3% (3.3 mmol/mol) less reduction in HbA1c during treatment with a DPP4I. Both the GG homozygotes and G-allele carriers had significantly smaller HbA1c reduction in comparison with the TT homozygotes. Conclusions: KCNQ1 rs163184 T &gt; G variant was associated with a reduced glycaemic response to DPP4I. The difference of 0.6% (6.5 mmol/mol) in HbA1c reduction between the TT and GG homozygotes might be of clinical significance if replicated in further studies.

Název v anglickém jazyce

KCNQ1 gene polymorphism is associated with glycaemic response to treatment with DPP-4 inhibitors

Popis výsledku anglicky

Aims: Only a few gene variants were associated with the response to dipeptidylpeptidase-4 inhibitors (DPP4I). KCNQ1 gene variants were previously related both to type 2 diabetes (T2D) and incretin effect. We hypothesized that T2D related KCNQ1 variants would be associated with smaller glucose-lowering effect of DDP4I. Methods: We performed a retrospective study in 137 Caucasian subjects with T2D who were followed for 6 months after initiation of DPP4I treatment. Genotyping for KCNQ1 rs163184 and rs151290 was performed using PCR-HRMA and PCR-RFLP methods, respectively. The main clinical outcome was reduction in HbA1c (DHbA1c) after 6-month DPP4I treatment. Results: KCNQ1 rs163184 T &gt; G variant was associated with the response to DPP4I treatment in genetic additive model (beta = -0.30, p = 0.022). For each G allele in the rs163184 genotype, we observed a 0.3% (3.3 mmol/mol) less reduction in HbA1c during treatment with a DPP4I. Both the GG homozygotes and G-allele carriers had significantly smaller HbA1c reduction in comparison with the TT homozygotes. Conclusions: KCNQ1 rs163184 T &gt; G variant was associated with a reduced glycaemic response to DPP4I. The difference of 0.6% (6.5 mmol/mol) in HbA1c reduction between the TT and GG homozygotes might be of clinical significance if replicated in further studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Research and Clinical Practice

ISSN

0168-8227

e-ISSN

—

Svazek periodika

130

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

6

Strana od-do

142-147

Kód UT WoS článku

000406460400019

EID výsledku v databázi Scopus

2-s2.0-85020811228