Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373789" target="_blank" >RIV/00216208:11130/17:10373789 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373789

Výsledek na webu

<a href="https://doi.org/10.1097/MPG.0000000000001470" target="_blank" >https://doi.org/10.1097/MPG.0000000000001470</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MPG.0000000000001470" target="_blank" >10.1097/MPG.0000000000001470</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine

Popis výsledku v původním jazyce

Objectives:Intestinal surgery is an important part of Crohn disease (CD) treatment in children. The aim of the present study was to compare the rate of endoscopic recurrence at the sixth month after ileocecal resection (ICR) in children with CD treated with azathioprine between patients who received prior antitumor necrosis factor alpha (anti-TNF-alpha) therapy and those who were not administered this therapy. Moreover, we tried to identify the potential risk factors for disease recurrence and describe the schedule of long-term follow-up after surgery. Methods:We prospectively collected data from pediatric patients with CD, who underwent ICR between October 2011 and June 2015 at our hospital and were treated with azathioprine monotherapy after ICR. We evaluated the endoscopic recurrence (Rutgeerts score) at the sixth month after ICR in all included patients. Results:Among 21 included patients, 13 achieved endoscopic remission (Rutgeerts score&lt;i2) at the sixth month after ICR. No difference was found between patients who received prior anti-TNF-alpha therapy and those who did not. We did not find any clinically relevant factors associated with endoscopic recurrence rate at the sixth month. Conclusions:Prior anti-TNF-alpha therapy does not seem to be a strong risk factor for endoscopic recurrence within 6 months after ICR. Further studies on large sample of patients are needed to identify potential predictors of disease recurrence.

Název v anglickém jazyce

Endoscopic Recurrence 6 Months After Ileocecal Resection in Children With Crohn Disease Treated With Azathioprine

Popis výsledku anglicky

Objectives:Intestinal surgery is an important part of Crohn disease (CD) treatment in children. The aim of the present study was to compare the rate of endoscopic recurrence at the sixth month after ileocecal resection (ICR) in children with CD treated with azathioprine between patients who received prior antitumor necrosis factor alpha (anti-TNF-alpha) therapy and those who were not administered this therapy. Moreover, we tried to identify the potential risk factors for disease recurrence and describe the schedule of long-term follow-up after surgery. Methods:We prospectively collected data from pediatric patients with CD, who underwent ICR between October 2011 and June 2015 at our hospital and were treated with azathioprine monotherapy after ICR. We evaluated the endoscopic recurrence (Rutgeerts score) at the sixth month after ICR in all included patients. Results:Among 21 included patients, 13 achieved endoscopic remission (Rutgeerts score&lt;i2) at the sixth month after ICR. No difference was found between patients who received prior anti-TNF-alpha therapy and those who did not. We did not find any clinically relevant factors associated with endoscopic recurrence rate at the sixth month. Conclusions:Prior anti-TNF-alpha therapy does not seem to be a strong risk factor for endoscopic recurrence within 6 months after ICR. Further studies on large sample of patients are needed to identify potential predictors of disease recurrence.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pediatric Gastroenterology &amp; Nutrition

ISSN

0277-2116

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

207-211

Kód UT WoS článku

000406471500015

EID výsledku v databázi Scopus

2-s2.0-85026322826