The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00525370" target="_blank" >RIV/61388971:_____/20:00525370 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/20:10410805 RIV/00064203:_____/20:10410805

Výsledek na webu

<a href="https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697909" target="_blank" >https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0039-1697909</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0039-1697909" target="_blank" >10.1055/s-0039-1697909</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease

Popis výsledku v původním jazyce

Introduction The incidence of Crohn's disease (CD) within the pediatric population is increasing worldwide. Despite a growing number of these patients receiving anti-tumor necrosis factor alpha therapy (anti-TNF-alpha), one-third of them still require surgery. There is limited data as to whether anti-TNF-alpha influences postoperative complications. We evaluated postoperative complications in patients who were or were not exposed to anti-TNF-alpha therapy in our institutional cohort.nnMaterials and Methods A retrospective review of CD patients who underwent abdominal surgery between September 2013 and September 2018 was performed. The patients were divided into two groups based on whether they were treated with anti-TNF-alpha within 90 days before surgery. Thirty-day postoperative complications were assessed using Clavien-Dindo classification (D-C), this examination included surgical site infections (SSIs), stoma complications, intra-abdominal septic complications, non-SSIs, bleeding, ileus, readmission rate, and return to the operating room. Mann-Whitney U -test, Fisher's exact test, and multivariate logistic regression analyses were used for statistical analysis.nnResults Sixty-five patients (41 males) with a median age of 16 years (range: 7-19) at the time of operation were identified. The most common surgery was ileocecal resection in 49 (75%) patients. Forty-three (66.2%) patients were treated with anti-TNF-alpha preoperatively. Seven patients (11%) experienced postoperative complications. There was no statistically significant difference in postoperative complication in patients who did or did not receive anti-TNF-alpha before surgery (D-C minor 2.3% vs. 4.6%, p = 1, D-C major 7% vs. 9.1%, p = 1).nnConclusion The use of anti-TNF-alpha in pediatric CD patients within the 90 days prior to their abdominal surgery was not associated with an increased risk of 30-day postoperative complications.

Název v anglickém jazyce

The Impact of Anti-Tumor Necrosis Factor Alpha Therapy on Postoperative Complications in Pediatric Crohn's Disease

Popis výsledku anglicky

Introduction The incidence of Crohn's disease (CD) within the pediatric population is increasing worldwide. Despite a growing number of these patients receiving anti-tumor necrosis factor alpha therapy (anti-TNF-alpha), one-third of them still require surgery. There is limited data as to whether anti-TNF-alpha influences postoperative complications. We evaluated postoperative complications in patients who were or were not exposed to anti-TNF-alpha therapy in our institutional cohort.nnMaterials and Methods A retrospective review of CD patients who underwent abdominal surgery between September 2013 and September 2018 was performed. The patients were divided into two groups based on whether they were treated with anti-TNF-alpha within 90 days before surgery. Thirty-day postoperative complications were assessed using Clavien-Dindo classification (D-C), this examination included surgical site infections (SSIs), stoma complications, intra-abdominal septic complications, non-SSIs, bleeding, ileus, readmission rate, and return to the operating room. Mann-Whitney U -test, Fisher's exact test, and multivariate logistic regression analyses were used for statistical analysis.nnResults Sixty-five patients (41 males) with a median age of 16 years (range: 7-19) at the time of operation were identified. The most common surgery was ileocecal resection in 49 (75%) patients. Forty-three (66.2%) patients were treated with anti-TNF-alpha preoperatively. Seven patients (11%) experienced postoperative complications. There was no statistically significant difference in postoperative complication in patients who did or did not receive anti-TNF-alpha before surgery (D-C minor 2.3% vs. 4.6%, p = 1, D-C major 7% vs. 9.1%, p = 1).nnConclusion The use of anti-TNF-alpha in pediatric CD patients within the 90 days prior to their abdominal surgery was not associated with an increased risk of 30-day postoperative complications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pediatric Surgery

ISSN

0939-7248

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

27-32

Kód UT WoS článku

000516618200005

EID výsledku v databázi Scopus

2-s2.0-85081268046