The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR-29G> A Affects Androgen Production in normal Human Small Antral Follicles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10373800" target="_blank" >RIV/00216208:11130/17:10373800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10373800

Výsledek na webu

<a href="https://doi.org/10.3389/fendo.2017.00122" target="_blank" >https://doi.org/10.3389/fendo.2017.00122</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fendo.2017.00122" target="_blank" >10.3389/fendo.2017.00122</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR-29G> A Affects Androgen Production in normal Human Small Antral Follicles

Popis výsledku v původním jazyce

Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP) FSHR -29G &gt; A (rs1394205) on hormonal conditions in humsan small antral follicles (hSAFs) obtained from women in the natural menstrual cycle. This study investigated the follicle fluid (FF) concentrations of anti-Mullerian hormone, estradiol, progesterone, androstenedione, and testosterone in hSAF in relation to the different genotypes of FSHR -29G &gt; A. FF from 362 follicles was collected in 95 women undergoing fertility preservation, who did not suffer from a disease that directly affected ovarian function. The testosterone levels of the minor A/A genotype were significantly increased compared to the A/G and the G/G genotype. Furthermore, significantly reduced androstenedione levels were observed for the G/G genotype, as compared to the A/G genotype, while the other hormones did not show statistical significant differences. In conclusion, the androgen levels of hSAF were significantly elevated in the minor SNP genotype in the FSHR promoter polymorphism FSHR -29G &gt; A.

Název v anglickém jazyce

The Common Follicle-Stimulating Hormone Receptor (FSHR) Promoter Polymorphism FSHR-29G> A Affects Androgen Production in normal Human Small Antral Follicles

Popis výsledku anglicky

Follicle-stimulating hormone receptors (FSHRs) are almost exclusively expressed on granulosa cells, and FSH action is probably most clearly reflected in intrafollicular hormone milieu of antral follicles. Little is known about the possible effects of the common single nucleotide polymorphism (SNP) FSHR -29G &gt; A (rs1394205) on hormonal conditions in humsan small antral follicles (hSAFs) obtained from women in the natural menstrual cycle. This study investigated the follicle fluid (FF) concentrations of anti-Mullerian hormone, estradiol, progesterone, androstenedione, and testosterone in hSAF in relation to the different genotypes of FSHR -29G &gt; A. FF from 362 follicles was collected in 95 women undergoing fertility preservation, who did not suffer from a disease that directly affected ovarian function. The testosterone levels of the minor A/A genotype were significantly increased compared to the A/G and the G/G genotype. Furthermore, significantly reduced androstenedione levels were observed for the G/G genotype, as compared to the A/G genotype, while the other hormones did not show statistical significant differences. In conclusion, the androgen levels of hSAF were significantly elevated in the minor SNP genotype in the FSHR promoter polymorphism FSHR -29G &gt; A.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

<a href="/cs/project/NT13770" target="_blank" >NT13770: Vyšetření instability DNA gamet, embryí a somatických buněk u dysfertility po úspěšné onkologické terapii ke zlepšení prognózy další reprodukce</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Endocrinology

ISSN

1664-2392

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

000402505400001

EID výsledku v databázi Scopus

2-s2.0-85020546477