Severe gastric ulcer as a first manifestation of systemic lupus erythematosus in a child

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F17%3A10374097" target="_blank" >RIV/00216208:11130/17:10374097 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/17:10374097

Výsledek na webu

<a href="https://doi.org/10.14735/amgh2017483" target="_blank" >https://doi.org/10.14735/amgh2017483</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amgh2017483" target="_blank" >10.14735/amgh2017483</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Severe gastric ulcer as a first manifestation of systemic lupus erythematosus in a child

Popis výsledku v původním jazyce

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical symptoms that can imitate a number of other diseases. It affects predominantly young women aged 20-40 years but cases diagnosed at a younger age are not unusual. We report a case of a young girl with failure to thrive and recurrent cystitis who presented abruptly with severe gastrointestinal manifestations requiring surgical treatment. Crohn&apos;s disease of the stomach was the most likely diagnosis, although no granuloma was found in tissue biopsies. In spite of intensive immunosuppressive therapy, complete healing of the deep stomach ulcers was not achieved. Five years after the disease manifestation, the patient developed lupus nephritis with autoimmune haemolytic anaemia and finally a diagnosis of SLE was established. Adequate therapeutic management of the disease consequently led to a significant improvement in the patient&apos;s clinical condition as well as laboratory results. This case report clearly points to the fact that in the case of atypical stomach ulcers, SLE must be considered in differential diagnosis. In addition, diagnosis of SLE may be extremely challenging, especially in cases with exclusive gastrointestinal and urinary symptoms.

Název v anglickém jazyce

Severe gastric ulcer as a first manifestation of systemic lupus erythematosus in a child

Popis výsledku anglicky

Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical symptoms that can imitate a number of other diseases. It affects predominantly young women aged 20-40 years but cases diagnosed at a younger age are not unusual. We report a case of a young girl with failure to thrive and recurrent cystitis who presented abruptly with severe gastrointestinal manifestations requiring surgical treatment. Crohn&apos;s disease of the stomach was the most likely diagnosis, although no granuloma was found in tissue biopsies. In spite of intensive immunosuppressive therapy, complete healing of the deep stomach ulcers was not achieved. Five years after the disease manifestation, the patient developed lupus nephritis with autoimmune haemolytic anaemia and finally a diagnosis of SLE was established. Adequate therapeutic management of the disease consequently led to a significant improvement in the patient&apos;s clinical condition as well as laboratory results. This case report clearly points to the fact that in the case of atypical stomach ulcers, SLE must be considered in differential diagnosis. In addition, diagnosis of SLE may be extremely challenging, especially in cases with exclusive gastrointestinal and urinary symptoms.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gastroenterologie a hepatologie

ISSN

1804-7874

e-ISSN

—

Svazek periodika

71

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

483-486

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85039742873