Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F18%3A10375334" target="_blank" >RIV/00216208:11130/18:10375334 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985823:_____/18:00489956 RIV/00159816:_____/18:00067044 RIV/00064203:_____/18:10375334

Výsledek na webu

<a href="https://doi.org/10.1080/13825585.2017.1290212" target="_blank" >https://doi.org/10.1080/13825585.2017.1290212</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/13825585.2017.1290212" target="_blank" >10.1080/13825585.2017.1290212</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Popis výsledku v původním jazyce

Aims: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).Methods: We recruited aMCI patients with (n=21) and without (n=21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n=22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.Results: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.Conclusions: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess pure aMCI, we may underestimate patients&apos; navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

Název v anglickém jazyce

Spatial navigation deficits in amnestic mild cognitive impairment with neuropsychiatric comorbidity

Popis výsledku anglicky

Aims: To find out whether neuropsychiatric comorbidity (comMCI) influences spatial navigation performance in amnestic mild cognitive impairment (aMCI).Methods: We recruited aMCI patients with (n=21) and without (n=21) neuropsychiatric comorbidity or alcohol abuse, matched for global cognitive impairment and cognitively healthy elderly participants (HE, n=22). They completed the Mini-Mental State Examination and a virtual Hidden Goal Task in egocentric, allocentric, and delayed recall subtests.Results: In allocentric navigation, aMCI and comMCI performed significantly worse than HE and similarly to each other. Although aMCI performed significantly worse at egocentric navigation than HE, they performed significantly better than patients with comMCI.Conclusions: Despite the growing burden of dementia and the prevalence of neuropsychiatric symptoms in the elderly population, comMCI remains under-studied. Since trials often assess pure aMCI, we may underestimate patients&apos; navigation and other deficits. This finding emphasizes the importance of taking account of the cognitive effects of psychiatric disorders in aMCI.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Aging, Neuropsychology and Cognition

ISSN

1382-5585

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

277-289

Kód UT WoS článku

000427551300009

EID výsledku v databázi Scopus

2-s2.0-85014466151