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Alcohol septal ablation in patients with severe septal hypertrophy

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10399169" target="_blank" >RIV/00216208:11130/20:10399169 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064203:_____/20:10399169

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1136/heartjnl-2019-315422" target="_blank" >10.1136/heartjnl-2019-315422</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Alcohol septal ablation in patients with severe septal hypertrophy

  • Popis výsledku v původním jazyce

    Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness &lt;30 mm Hg to those with &gt;=30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57+-14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness &gt;=30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4+-4.3 years and 5.1+-4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS &lt;30 mm group and the IVS &gt;=30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16+-20 vs 16+-16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS &lt;30 mm group and IVS &gt;=30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS &gt;=30 mm is similar to those with IVS &lt;30mm. However, long-term all-cause and cardiac mortality rates are worse in the &gt;=30 mm group. (C) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions.

  • Název v anglickém jazyce

    Alcohol septal ablation in patients with severe septal hypertrophy

  • Popis výsledku anglicky

    Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness &lt;30 mm Hg to those with &gt;=30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57+-14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness &gt;=30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4+-4.3 years and 5.1+-4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS &lt;30 mm group and the IVS &gt;=30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16+-20 vs 16+-16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS &lt;30 mm group and IVS &gt;=30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS &gt;=30 mm is similar to those with IVS &lt;30mm. However, long-term all-cause and cardiac mortality rates are worse in the &gt;=30 mm group. (C) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30201 - Cardiac and Cardiovascular systems

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Heart

  • ISSN

    1355-6037

  • e-ISSN

  • Svazek periodika

    106

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    5

  • Strana od-do

    462-466

  • Kód UT WoS článku

    000530040400014

  • EID výsledku v databázi Scopus

    2-s2.0-85071746893