Alcohol septal ablation in patients with severe septal hypertrophy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10399169" target="_blank" >RIV/00216208:11130/20:10399169 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064203:_____/20:10399169
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=acYbZtFzT9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/heartjnl-2019-315422" target="_blank" >10.1136/heartjnl-2019-315422</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Alcohol septal ablation in patients with severe septal hypertrophy
Popis výsledku v původním jazyce
Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with >=30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57+-14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness >=30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4+-4.3 years and 5.1+-4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS <30 mm group and the IVS >=30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16+-20 vs 16+-16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS <30 mm group and IVS >=30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS >=30 mm is similar to those with IVS <30mm. However, long-term all-cause and cardiac mortality rates are worse in the >=30 mm group. (C) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions.
Název v anglickém jazyce
Alcohol septal ablation in patients with severe septal hypertrophy
Popis výsledku anglicky
Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with >=30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57+-14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness >=30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4+-4.3 years and 5.1+-4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS <30 mm group and the IVS >=30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16+-20 vs 16+-16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS <30 mm group and IVS >=30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS >=30 mm is similar to those with IVS <30mm. However, long-term all-cause and cardiac mortality rates are worse in the >=30 mm group. (C) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Heart
ISSN
1355-6037
e-ISSN
—
Svazek periodika
106
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
462-466
Kód UT WoS článku
000530040400014
EID výsledku v databázi Scopus
2-s2.0-85071746893