Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F22%3A10441719" target="_blank" >RIV/00216208:11130/22:10441719 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9x90uxXEo_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9x90uxXEo_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.stemcr.2022.02.007" target="_blank" >10.1016/j.stemcr.2022.02.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Popis výsledku v původním jazyce

In our recent publication in Stem Cell Reports (Lobo de Figueiredo-Pontes et al., 2021), we assessed the role of NK cells on hematopoietic stem cell (HSC) fate during HSC transplantation and concluded that NK cells, possibly via secretion of cytokines (and in particular IFNγ), negatively affect HSC frequency and function. In their letter in this issue of Stem Cell Reports, Merli and colleagues report carrying out an interesting attempt to translate our observations to clinics (Merli et al., 2022). They performed a retrospective analysis of 2 cohorts of pediatric patients transplanted after ex vivo T cell depletion (Locatelli et al., 2017; Merli et al., 2021; Lang et al., 2014) and concluded that the amount of NK cells in the graft does not have an impact in the transplantation outcome. While we acknowledge the value of their analysis, we believe that there are critical factors between both studies that prevent Merli et al. from reaching our same conclusions.

Název v anglickém jazyce

Response to NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical stem cell transplantation

Popis výsledku anglicky

In our recent publication in Stem Cell Reports (Lobo de Figueiredo-Pontes et al., 2021), we assessed the role of NK cells on hematopoietic stem cell (HSC) fate during HSC transplantation and concluded that NK cells, possibly via secretion of cytokines (and in particular IFNγ), negatively affect HSC frequency and function. In their letter in this issue of Stem Cell Reports, Merli and colleagues report carrying out an interesting attempt to translate our observations to clinics (Merli et al., 2022). They performed a retrospective analysis of 2 cohorts of pediatric patients transplanted after ex vivo T cell depletion (Locatelli et al., 2017; Merli et al., 2021; Lang et al., 2014) and concluded that the amount of NK cells in the graft does not have an impact in the transplantation outcome. While we acknowledge the value of their analysis, we believe that there are critical factors between both studies that prevent Merli et al. from reaching our same conclusions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Stem Cell Reports

ISSN

2213-6711

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

446-447

Kód UT WoS článku

000767602800002

EID výsledku v databázi Scopus

2-s2.0-85125618242