Hyperoxic ventilatory response in infants is related to nocturnal hypoxemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F24%3A10472111" target="_blank" >RIV/00216208:11130/24:10472111 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/24:10472111

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h2dXbMV5pD" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=h2dXbMV5pD</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00512-2023" target="_blank" >10.1183/23120541.00512-2023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hyperoxic ventilatory response in infants is related to nocturnal hypoxemia

Popis výsledku v původním jazyce

Background The carotid bodies primarily serve as oxaemia sensors that affect tidal breathing. Their function has not been studied in infants with nocturnal hypoxaemia yet. This cross-sectional study aimed to characterise the hyperoxic ventilatory response (HVR) in infants and its relationship to nocturnal hypoxaemia.Methods The HVR was analysed in term infants aged &lt;24 months with childhood interstitial lung disease (chILD), those with severe recurrent wheezing (wheeze), and non-respiratory controls. The HVR timing was characterised using hyperoxia response time (HRT1) and HVR magnitude was characterised by the relative change in minute ventilation between normoxia and 30-s hyperoxia (VE_dH30). Time spent with an arterial haemoglobin oxygen saturation (SpO2) &lt;90% during overnight monitoring (t90) was estimated.Results HVR data were available for 23 infants with chILD, 24 with wheezing, and 14 control infants. A significant decrease in minute ventilation under 30 s of hyperoxia was observed in all patients. HRT1 was shorter in chILD (5.6+-1.2 s) and wheeze (5.9+-1.5 s) groups than in the controls (12.6+-5.5 s) (ANOVA p-value &lt;0.001). VE_dH30 was increased in the chILD group (24.3+-8.0%) compared with that in the controls (14.7+-9.2%), p=0.003. T90 was abnormal in the wheeze (8.0+-5.0%) and chILD (32.7+-25.8%) groups and higher in the chILD group than in the controls (p&lt;0.001). HRT1 negatively correlated with t90 in all groups.Conclusion Significant differences in HVR timing and magnitude were noted in the chILD, wheeze, and control groups. A relationship between nocturnal hypoxaemia and HRT1 was proposed. HVR characterisation may help identify patients with abnormal nocturnal SpO2.

Název v anglickém jazyce

Hyperoxic ventilatory response in infants is related to nocturnal hypoxemia

Popis výsledku anglicky

Background The carotid bodies primarily serve as oxaemia sensors that affect tidal breathing. Their function has not been studied in infants with nocturnal hypoxaemia yet. This cross-sectional study aimed to characterise the hyperoxic ventilatory response (HVR) in infants and its relationship to nocturnal hypoxaemia.Methods The HVR was analysed in term infants aged &lt;24 months with childhood interstitial lung disease (chILD), those with severe recurrent wheezing (wheeze), and non-respiratory controls. The HVR timing was characterised using hyperoxia response time (HRT1) and HVR magnitude was characterised by the relative change in minute ventilation between normoxia and 30-s hyperoxia (VE_dH30). Time spent with an arterial haemoglobin oxygen saturation (SpO2) &lt;90% during overnight monitoring (t90) was estimated.Results HVR data were available for 23 infants with chILD, 24 with wheezing, and 14 control infants. A significant decrease in minute ventilation under 30 s of hyperoxia was observed in all patients. HRT1 was shorter in chILD (5.6+-1.2 s) and wheeze (5.9+-1.5 s) groups than in the controls (12.6+-5.5 s) (ANOVA p-value &lt;0.001). VE_dH30 was increased in the chILD group (24.3+-8.0%) compared with that in the controls (14.7+-9.2%), p=0.003. T90 was abnormal in the wheeze (8.0+-5.0%) and chILD (32.7+-25.8%) groups and higher in the chILD group than in the controls (p&lt;0.001). HRT1 negatively correlated with t90 in all groups.Conclusion Significant differences in HVR timing and magnitude were noted in the chILD, wheeze, and control groups. A relationship between nocturnal hypoxaemia and HRT1 was proposed. HVR characterisation may help identify patients with abnormal nocturnal SpO2.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

<a href="/cs/project/NV19-07-00210" target="_blank" >NV19-07-00210: Primární ciliární dyskineze: Genetické, strukturální a funkční determinanty průběhu a prognózy onemocnění.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ERJ Open Research

ISSN

2312-0541

e-ISSN

2312-0541

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

00512-2023

Kód UT WoS článku

001159220700001

EID výsledku v databázi Scopus

2-s2.0-85186194087