Abnormal Hyperoxia Ventilatory Response in Infants With Cystic Fibrosis Is Related to Ventilation Inhomogeneity: A Physiology Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24510%2F25%3A00014622" target="_blank" >RIV/46747885:24510/25:00014622 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.27399" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/ppul.27399</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Abnormal Hyperoxia Ventilatory Response in Infants With Cystic Fibrosis Is Related to Ventilation Inhomogeneity: A Physiology Study

Popis výsledku v původním jazyce

Background: Ventilatory response to hyperoxia (HVR) char-acterizes peripheral chemoreceptor function. Impaired HVRmay be found in infants born preterm and in infants sufferingfrom nocturnal hypoxemia. We aimed to evaluate HVR ininfants with cystic fibrosis (CF) and to investigate its relation-ship to ventilation inhomogeneity. Methods: Twenty‐five infants with CF and uncomplicatedperinatal history underwent HVR testing and nitrogen multiple breath washout test (N2‐MBW). Hyperoxia response time(HRT1) and relative change in minute ventilation after 30 s ofhyperoxia (VE_dH30) were estimated using custom made software for HVR analysis. Lung clearance index (LCI) andfunctional residual capacity (FRC) were measured using N2‐MBW and expressed as z‐scores. Fifteen non‐respiratory con-trols were recruited. Results: Mean age at testing ± standard deviation was59.6 ± 14.4 weeks in CF and 61.1 ± 50.9 in controls. All infantswere born in term (%62 37th week of gestation) and none of themneeded oxygen‐therapy or ventilatory support afterbirth. Minute ventilation decreased significantly under 30 shyperoxia both in CF and controls (both p %60 0.001) because ofdecrease in tidal volume, respiratory rate did not change ineither group. HRT1 was shorter (6.0 ± 1.4 s) in CF than incontrols (13.0 ± 9.3 s), p %60 0.001. VE_dH30 was greater in CF(19.6 ± 7.4%) than in controls (12.7 ± 7.8 s), p = 0.008. In CF,VE_dH30 correlated significantly with LCI (r = 0.572,p = 0.003), no such correlation was found in controls. Conclusion: Ventilatory response to hyperoxia is abnormal inCF infants indicating increased basal activity of peripheralchemoreceptor. Depth of HVR (VE_dH30) significantly corre-lates with lung ventilation inhomogeneity.

Název v anglickém jazyce

Abnormal Hyperoxia Ventilatory Response in Infants With Cystic Fibrosis Is Related to Ventilation Inhomogeneity: A Physiology Study

Popis výsledku anglicky

Background: Ventilatory response to hyperoxia (HVR) char-acterizes peripheral chemoreceptor function. Impaired HVRmay be found in infants born preterm and in infants sufferingfrom nocturnal hypoxemia. We aimed to evaluate HVR ininfants with cystic fibrosis (CF) and to investigate its relation-ship to ventilation inhomogeneity. Methods: Twenty‐five infants with CF and uncomplicatedperinatal history underwent HVR testing and nitrogen multiple breath washout test (N2‐MBW). Hyperoxia response time(HRT1) and relative change in minute ventilation after 30 s ofhyperoxia (VE_dH30) were estimated using custom made software for HVR analysis. Lung clearance index (LCI) andfunctional residual capacity (FRC) were measured using N2‐MBW and expressed as z‐scores. Fifteen non‐respiratory con-trols were recruited. Results: Mean age at testing ± standard deviation was59.6 ± 14.4 weeks in CF and 61.1 ± 50.9 in controls. All infantswere born in term (%62 37th week of gestation) and none of themneeded oxygen‐therapy or ventilatory support afterbirth. Minute ventilation decreased significantly under 30 shyperoxia both in CF and controls (both p %60 0.001) because ofdecrease in tidal volume, respiratory rate did not change ineither group. HRT1 was shorter (6.0 ± 1.4 s) in CF than incontrols (13.0 ± 9.3 s), p %60 0.001. VE_dH30 was greater in CF(19.6 ± 7.4%) than in controls (12.7 ± 7.8 s), p = 0.008. In CF,VE_dH30 correlated significantly with LCI (r = 0.572,p = 0.003), no such correlation was found in controls. Conclusion: Ventilatory response to hyperoxia is abnormal inCF infants indicating increased basal activity of peripheralchemoreceptor. Depth of HVR (VE_dH30) significantly corre-lates with lung ventilation inhomogeneity.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů