Reflex zone stimulation reduces ventilation inhomogeneity in cystic fibrosis: A randomised controlled cross-over study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F21%3A10425319" target="_blank" >RIV/00064203:_____/21:10425319 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/21:10425319

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5riLQnqErw" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=5riLQnqErw</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ppul.25350" target="_blank" >10.1002/ppul.25350</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Reflex zone stimulation reduces ventilation inhomogeneity in cystic fibrosis: A randomised controlled cross-over study

Popis výsledku v původním jazyce

BACKGROUND: The reflex zone stimulation technique (RST) activates complex motor responses and has a positive impact on the locomotor system. This technique may also indirectly affect breathing; however, the use of this technique as adjunct of the treatment of cystic fibrosis (CF) has not yet been characterised. METHODS: We performed a randomised controlled single-centre interventional trial to evaluate the short-term effects of RST on lung function in 21 paediatric CF patients with normal baseline spirometry. The effect of 30 minutes of RST was compared to that of sham therapy in a crossover design. The interventions were performed in random order and planned 6 months apart. The primary outcome was a change in global ventilation inhomogeneity after intervention, assessed by lung clearance index (LCI(2.5) ) derived from a nitrogen multiple breath washout test. Secondary outcomes included changes in regional ventilation inhomogeneity (indices of acinar [Sacin*Vt] and conductive airway [Scond*Vt] inhomogeneity) and spirometry parameters (inspiratory capacity, forced vital capacity, and forced expiratory volume in 1 second). Trunk deformity was assessed by physiotherapists at study entry. RESULTS: After the RST intervention, the LCI(2.5) (p = 0.004) and Scond*Vt (p = 0.009) decreased significantly, while inspiratory capacity increased (p = 0.012). In the sham-therapy group, none of the parameters changed significantly. Trunk deformity was seen in 76.5% of all patients, and 92.9% of those with trunk deformity showed a decrease in LCI(2.5) after RST. CONCLUSION: RST has multiple positive short-term effects on lung function, especially in CF patients with trunk deformities. This article is protected by copyright. All rights reserved.

Název v anglickém jazyce

Reflex zone stimulation reduces ventilation inhomogeneity in cystic fibrosis: A randomised controlled cross-over study

Popis výsledku anglicky

BACKGROUND: The reflex zone stimulation technique (RST) activates complex motor responses and has a positive impact on the locomotor system. This technique may also indirectly affect breathing; however, the use of this technique as adjunct of the treatment of cystic fibrosis (CF) has not yet been characterised. METHODS: We performed a randomised controlled single-centre interventional trial to evaluate the short-term effects of RST on lung function in 21 paediatric CF patients with normal baseline spirometry. The effect of 30 minutes of RST was compared to that of sham therapy in a crossover design. The interventions were performed in random order and planned 6 months apart. The primary outcome was a change in global ventilation inhomogeneity after intervention, assessed by lung clearance index (LCI(2.5) ) derived from a nitrogen multiple breath washout test. Secondary outcomes included changes in regional ventilation inhomogeneity (indices of acinar [Sacin*Vt] and conductive airway [Scond*Vt] inhomogeneity) and spirometry parameters (inspiratory capacity, forced vital capacity, and forced expiratory volume in 1 second). Trunk deformity was assessed by physiotherapists at study entry. RESULTS: After the RST intervention, the LCI(2.5) (p = 0.004) and Scond*Vt (p = 0.009) decreased significantly, while inspiratory capacity increased (p = 0.012). In the sham-therapy group, none of the parameters changed significantly. Trunk deformity was seen in 76.5% of all patients, and 92.9% of those with trunk deformity showed a decrease in LCI(2.5) after RST. CONCLUSION: RST has multiple positive short-term effects on lung function, especially in CF patients with trunk deformities. This article is protected by copyright. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatric Pulmonology [online]

ISSN

1099-0496

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

BD - Bangladéšská lidová republika

Počet stran výsledku

8

Strana od-do

1558-1565

Kód UT WoS článku

000628390000001

EID výsledku v databázi Scopus

2-s2.0-85102474466