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Repeatability of lung clearance index in infants with cystic fibrosis and recurrent wheeze

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F22%3A10443000" target="_blank" >RIV/00064203:_____/22:10443000 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11130/22:10443000 RIV/00216208:11320/22:10443000

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jp6KdlsRkX" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Jp6KdlsRkX</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ppul.25921" target="_blank" >10.1002/ppul.25921</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Repeatability of lung clearance index in infants with cystic fibrosis and recurrent wheeze

  • Popis výsledku v původním jazyce

    OBJECTIVES: To describe the short- and medium-term repeatability of lung clearance index (LCI(2.5) ) in infants and calculate the number of patients needed to enrol in a study (N) using LCI(2.5) as a primary outcome. METHODS: An 8-month follow-up observational study was employed for assessing short-term [coefficient of repeatability (CR) and intraclass correlation (ICC)] and medium-term repeatability (Bland-Altman method) of LCI(2.5) in infants with cystic fibrosis (CF) or recurrent wheeze (RW) measured by the nitrogen multiple-breath washout test (N(2) -MBW). Using these variability data, the N to reach 90% test power at the level of statistical significance (0.05) was calculated. RESULTS: Forty infants with CF and 21 with RW were enrolled. Initial N(2) -MBW testing was successful in 33 and 17 patients, respectively. Follow-up data were available for 23 and 11 infants, respectively. Short-term repeatability of LCI(2.5) was high (CR = 1.10 and 1.04 in CF and RW patients, respectively; ICC = 0.88 and 0.83 in CF and RW patients, respectively). The between-subject standard deviation was &lt;13% of the actual LCI(2.5) value. In clinically stable patients, LCI(2.5) did not significantly change during the 8-month follow-up. Mean LCI(2.5) change was -0.08 (1% of baseline) in CF and -0.05 (0.6%) in RW, with 95% limits of agreement being (-1.70; 1.53) in CF and (-1.51; 1.40) in RW patients. N = 23 infants if both intra-group differences of LCI(2.5) and minimal difference to be detected would be 2.0. CONCLUSION: N(2) -MBW may be a reproducible tool with reasonable test power to detect differences in infant studies. This article is protected by copyright. All rights reserved.

  • Název v anglickém jazyce

    Repeatability of lung clearance index in infants with cystic fibrosis and recurrent wheeze

  • Popis výsledku anglicky

    OBJECTIVES: To describe the short- and medium-term repeatability of lung clearance index (LCI(2.5) ) in infants and calculate the number of patients needed to enrol in a study (N) using LCI(2.5) as a primary outcome. METHODS: An 8-month follow-up observational study was employed for assessing short-term [coefficient of repeatability (CR) and intraclass correlation (ICC)] and medium-term repeatability (Bland-Altman method) of LCI(2.5) in infants with cystic fibrosis (CF) or recurrent wheeze (RW) measured by the nitrogen multiple-breath washout test (N(2) -MBW). Using these variability data, the N to reach 90% test power at the level of statistical significance (0.05) was calculated. RESULTS: Forty infants with CF and 21 with RW were enrolled. Initial N(2) -MBW testing was successful in 33 and 17 patients, respectively. Follow-up data were available for 23 and 11 infants, respectively. Short-term repeatability of LCI(2.5) was high (CR = 1.10 and 1.04 in CF and RW patients, respectively; ICC = 0.88 and 0.83 in CF and RW patients, respectively). The between-subject standard deviation was &lt;13% of the actual LCI(2.5) value. In clinically stable patients, LCI(2.5) did not significantly change during the 8-month follow-up. Mean LCI(2.5) change was -0.08 (1% of baseline) in CF and -0.05 (0.6%) in RW, with 95% limits of agreement being (-1.70; 1.53) in CF and (-1.51; 1.40) in RW patients. N = 23 infants if both intra-group differences of LCI(2.5) and minimal difference to be detected would be 2.0. CONCLUSION: N(2) -MBW may be a reproducible tool with reasonable test power to detect differences in infant studies. This article is protected by copyright. All rights reserved.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30209 - Paediatrics

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2022

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Pediatric Pulmonology [online]

  • ISSN

    1099-0496

  • e-ISSN

    1099-0496

  • Svazek periodika

    57

  • Číslo periodika v rámci svazku

    7

  • Stát vydavatele periodika

    BD - Bangladéšská lidová republika

  • Počet stran výsledku

    10

  • Strana od-do

    1608-1617

  • Kód UT WoS článku

    000787387500001

  • EID výsledku v databázi Scopus

    2-s2.0-85128745795