Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10503789" target="_blank" >RIV/00216208:11130/25:10503789 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/25:10503789

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7Lu-J1wd1W" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7Lu-J1wd1W</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00234-025-03794-9" target="_blank" >10.1007/s00234-025-03794-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL

Popis výsledku v původním jazyce

BACKGROUND: Arterial spin labeling (ASL) MRI is a non-invasive perfusion imaging technique with potential for assessing hemodynamics in children. However, understanding hemodynamic changes in developing brains remains challenging. This study investigates the impact of normal brain development on ASL-derived cerebral blood flow (CBF) and arterial transit time (ATT) in MR-negative children. METHODS: Thirty-two pediatric subjects (ages 0.7-17.9 years, mean 9.3 +- 5.3y, 19 male) with MR-negative findings were retrospectively included. Four pseudo-continuous ASL (PCASL) scans were acquired: single-delay (PLD 1525 or 2025 ms) and multi-delay (3 or 7 delays). CBF and ATT in supratentorial gray matter (GM), white matter (WM), and total-brain (TB) regions were analyzed using paired t-tests, Cohen&apos;s d, Spearman correlation, and mixed linear regression models. RESULTS: Single-delay CBF was significantly higher than 3-delay CBF in GM and WM (p &lt; 0.001 PLD 2025 ms; p = 0.02 PLD 1525 ms). WM and TB CBF correlated negatively with age (rho=-0.56, p &lt; 0.001), whereas GM CBF showed no significant correlation (rho=-0.03, p = 0.87); the trends differed significantly (p = 0.01). GM and TB ATT increased with age (r(2) &gt; 0.11, p &lt; 0.021). WM and TB CBF correlated with WM and combined WM/GM volumes (rho=-0.42, p = 0.02; rho=-0.46, p = 0.008). CONCLUSION: GM and WM exhibit distinct age-related hemodynamic patterns. WM perfusion declines with age and correlates with WM volume, while GM perfusion remains stable. The progressive increase in GM ATT highlights the need for cautious interpretation of single-delay ASL data in pediatric studies.

Název v anglickém jazyce

Age-related changes in cerebral blood flow and arterial transit time in children: insights from single- and multi-delay ASL

Popis výsledku anglicky

BACKGROUND: Arterial spin labeling (ASL) MRI is a non-invasive perfusion imaging technique with potential for assessing hemodynamics in children. However, understanding hemodynamic changes in developing brains remains challenging. This study investigates the impact of normal brain development on ASL-derived cerebral blood flow (CBF) and arterial transit time (ATT) in MR-negative children. METHODS: Thirty-two pediatric subjects (ages 0.7-17.9 years, mean 9.3 +- 5.3y, 19 male) with MR-negative findings were retrospectively included. Four pseudo-continuous ASL (PCASL) scans were acquired: single-delay (PLD 1525 or 2025 ms) and multi-delay (3 or 7 delays). CBF and ATT in supratentorial gray matter (GM), white matter (WM), and total-brain (TB) regions were analyzed using paired t-tests, Cohen&apos;s d, Spearman correlation, and mixed linear regression models. RESULTS: Single-delay CBF was significantly higher than 3-delay CBF in GM and WM (p &lt; 0.001 PLD 2025 ms; p = 0.02 PLD 1525 ms). WM and TB CBF correlated negatively with age (rho=-0.56, p &lt; 0.001), whereas GM CBF showed no significant correlation (rho=-0.03, p = 0.87); the trends differed significantly (p = 0.01). GM and TB ATT increased with age (r(2) &gt; 0.11, p &lt; 0.021). WM and TB CBF correlated with WM and combined WM/GM volumes (rho=-0.42, p = 0.02; rho=-0.46, p = 0.008). CONCLUSION: GM and WM exhibit distinct age-related hemodynamic patterns. WM perfusion declines with age and correlates with WM volume, while GM perfusion remains stable. The progressive increase in GM ATT highlights the need for cautious interpretation of single-delay ASL data in pediatric studies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroradiology

ISSN

0028-3940

e-ISSN

1432-1920

Svazek periodika

67

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

14

Strana od-do

3335-3348

Kód UT WoS článku

001589403000001

EID výsledku v databázi Scopus

2-s2.0-105018214348