Kinematic alignment in total knee replacement successfully restores the native knee phenotype in the short term

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F25%3A10505300" target="_blank" >RIV/00216208:11130/25:10505300 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZGHrn08Am1" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ZGHrn08Am1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jeo2.70561" target="_blank" >10.1002/jeo2.70561</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Kinematic alignment in total knee replacement successfully restores the native knee phenotype in the short term

Popis výsledku v původním jazyce

PURPOSE: The goal of kinematic alignment (KA) in total knee arthroplasty (TKA) is to bring back the natural knee phenotypes. This study compared postoperative functional phenotypes in KA-TKAs against native phenotypes of healthy young Iranians, addressing the need for population-specific alignment targets. METHODS: The study analysed 300 KA-TKAs and 150 native phenotypes of healthy young Iranians. Full-limb radiographs were used to measure alignment parameters and classify phenotypes. Patient-reported outcomes were collected to assess functional recovery. The research focused on phenotype restoration, gender differences and ethnic variations in constitutional alignment. RESULTS: KA-TKA successfully restored constitutional knee phenotypes in 91.7% of patients. The top five phenotypes showed similar proportions in both TKA (52.7%) and control (54.2%) groups. Females demonstrated higher phenotype restoration rates, particularly for valgus-dominant phenotypes. The Forgotten Joint Scores at 3 months showed a significant improvement of 18% when comparing phenotype-matched patients to outliers. KA-TKA cases that failed to match the control phenotype distribution amounted to 8.3%, and these cases showed significant preoperative deformities as well as high body mass index. The research demonstrated important differences in ethnic populations since 53.7% of Iranians showed constitutional varus compared to 28.3% of Swiss individuals. CONCLUSION: The study demonstrates that KA-TKA successfully restores native knee phenotypes to most Iranian patients. The alignment targets require customization for population-specific standards together with attention to gender-specific variations. LEVEL OF EVIDENCE: Level III.

Název v anglickém jazyce

Kinematic alignment in total knee replacement successfully restores the native knee phenotype in the short term

Popis výsledku anglicky

PURPOSE: The goal of kinematic alignment (KA) in total knee arthroplasty (TKA) is to bring back the natural knee phenotypes. This study compared postoperative functional phenotypes in KA-TKAs against native phenotypes of healthy young Iranians, addressing the need for population-specific alignment targets. METHODS: The study analysed 300 KA-TKAs and 150 native phenotypes of healthy young Iranians. Full-limb radiographs were used to measure alignment parameters and classify phenotypes. Patient-reported outcomes were collected to assess functional recovery. The research focused on phenotype restoration, gender differences and ethnic variations in constitutional alignment. RESULTS: KA-TKA successfully restored constitutional knee phenotypes in 91.7% of patients. The top five phenotypes showed similar proportions in both TKA (52.7%) and control (54.2%) groups. Females demonstrated higher phenotype restoration rates, particularly for valgus-dominant phenotypes. The Forgotten Joint Scores at 3 months showed a significant improvement of 18% when comparing phenotype-matched patients to outliers. KA-TKA cases that failed to match the control phenotype distribution amounted to 8.3%, and these cases showed significant preoperative deformities as well as high body mass index. The research demonstrated important differences in ethnic populations since 53.7% of Iranians showed constitutional varus compared to 28.3% of Swiss individuals. CONCLUSION: The study demonstrates that KA-TKA successfully restores native knee phenotypes to most Iranian patients. The alignment targets require customization for population-specific standards together with attention to gender-specific variations. LEVEL OF EVIDENCE: Level III.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Experimental Orthopaedics

ISSN

2197-1153

e-ISSN

2197-1153

Svazek periodika

12

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

e70561

Kód UT WoS článku

001614373000001

EID výsledku v databázi Scopus

2-s2.0-105021874523