The dynamics of cancer stem cells
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F12%3A10123820" target="_blank" >RIV/00216208:11140/12:10123820 - isvavai.cz</a>
Výsledek na webu
<a href="http://www.elis.sk/download_file.php?product_id=2991&session_id=jpa5s76uapba31c9g19nl9hbm7" target="_blank" >http://www.elis.sk/download_file.php?product_id=2991&session_id=jpa5s76uapba31c9g19nl9hbm7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2012_092" target="_blank" >10.4149/neo_2012_092</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The dynamics of cancer stem cells
Popis výsledku v původním jazyce
With the formulation of the hierarchical model of tumor cell organization, cancer stem cells came to the forefornt of cancer biology. As the only self-renewing tumor cells, they were made responsible for continuous tumor growth and their intrinsic self-protection ability was postulated to underlie cancer therapy resistance and/or recurrence. The concept of migrating cancer stem cells extended the relevance of the hierarchical cancer cell model to issue of cancer progression, with the crucial experimental evidence being provided by the demonstration that epithelial mesenchymal transition can convey stemness. Accordingly, cancer stem cells probably represent a highly dynamic cell population continuously differentiating and being continuously replenishedby processes like mesenchymal epithelial transition and epithelial mesenchymal transition, respectively. Consequently, from the point of view of therapeutic targeting, cancer stem cells obviously do not represent a fixed target population
Název v anglickém jazyce
The dynamics of cancer stem cells
Popis výsledku anglicky
With the formulation of the hierarchical model of tumor cell organization, cancer stem cells came to the forefornt of cancer biology. As the only self-renewing tumor cells, they were made responsible for continuous tumor growth and their intrinsic self-protection ability was postulated to underlie cancer therapy resistance and/or recurrence. The concept of migrating cancer stem cells extended the relevance of the hierarchical cancer cell model to issue of cancer progression, with the crucial experimental evidence being provided by the demonstration that epithelial mesenchymal transition can convey stemness. Accordingly, cancer stem cells probably represent a highly dynamic cell population continuously differentiating and being continuously replenishedby processes like mesenchymal epithelial transition and epithelial mesenchymal transition, respectively. Consequently, from the point of view of therapeutic targeting, cancer stem cells obviously do not represent a fixed target population
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neoplasma
ISSN
0028-2685
e-ISSN
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Svazek periodika
59
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
7
Strana od-do
700-707
Kód UT WoS článku
000310820200014
EID výsledku v databázi Scopus
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