Cerebellar degeneration in lurcher mice under confocal laser scanning microscope
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134171" target="_blank" >RIV/00216208:11140/13:10134171 - isvavai.cz</a>
Výsledek na webu
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jemt.22198/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jemt.22198/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jemt.22198" target="_blank" >10.1002/jemt.22198</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cerebellar degeneration in lurcher mice under confocal laser scanning microscope
Popis výsledku v původním jazyce
Lurcher mutant mice represent a natural model of genetically-determined olivocerebellar degeneration caused by a mutation in the ?2 glutamate receptor gene. They suffer from progressive postnatal loss of cerebellar Purkinje cells and a decrease of granule cells and inferior olive neurons. Their wild type littermates serve as healthy controls. A confocal laser scanning microscope was used aiming investigation the dynamics of changes in the cerebellar cortex of Lurcher and wild type mice derived from twostrains during the period of 8-21 postnatal days. Fluorescent double-staining was used to visualize mainly the Purkinje cells in cerebellar slices. In wild types, only normal Purkinje cells of round or regular drop-shaped were present, when staining intensity of other individual cell structures differed in dependence on the age of the animal. In Lurcher mutants, there were still some normal-shaped cells. Nevertheless, depending on the animal's age, a wide variety of stages of the cell de
Název v anglickém jazyce
Cerebellar degeneration in lurcher mice under confocal laser scanning microscope
Popis výsledku anglicky
Lurcher mutant mice represent a natural model of genetically-determined olivocerebellar degeneration caused by a mutation in the ?2 glutamate receptor gene. They suffer from progressive postnatal loss of cerebellar Purkinje cells and a decrease of granule cells and inferior olive neurons. Their wild type littermates serve as healthy controls. A confocal laser scanning microscope was used aiming investigation the dynamics of changes in the cerebellar cortex of Lurcher and wild type mice derived from twostrains during the period of 8-21 postnatal days. Fluorescent double-staining was used to visualize mainly the Purkinje cells in cerebellar slices. In wild types, only normal Purkinje cells of round or regular drop-shaped were present, when staining intensity of other individual cell structures differed in dependence on the age of the animal. In Lurcher mutants, there were still some normal-shaped cells. Nevertheless, depending on the animal's age, a wide variety of stages of the cell de
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EA - Morfologické obory a cytologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Microscopy Research and Technique
ISSN
1059-910X
e-ISSN
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Svazek periodika
76
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
545-551
Kód UT WoS článku
000317299500014
EID výsledku v databázi Scopus
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