Lurcher Mouse

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10134173" target="_blank" >RIV/00216208:11140/13:10134173 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/content/pdf/bfm%3A978-94-007-1333-8%2F1.pdf" target="_blank" >http://link.springer.com/content/pdf/bfm%3A978-94-007-1333-8%2F1.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-007-1333-8" target="_blank" >10.1007/978-94-007-1333-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lurcher Mouse

Popis výsledku v původním jazyce

Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degeneration. It is caused by a mutation in the ?2 glutamate receptor subunit encoding gene. The gain of function mutation changes the receptor into a leaky membrane channel leading to chronic depolarization of the cells expressing the receptor. Heterozygous Lurcher mice suffer from virtually complete postnatal loss of cerebellar Purkinje cells and reduction of granule, stellate and basket cells and inferior olive neurons and relatively mild changes in the deep cerebellar nuclei. The death of Purkinje cells is a primary effect of the mutation and it shows features of apoptosis, autophagy and necrosis. Extinction of the granule, stellate and basket cells and inferior olive neurons is a target-related cell death. Lurcher mice display neurochemical and metabolic changes, abnormalities in the neurotransmitter and receptor systems, endocrine and immune abnormalities and multiple behavioral deficits.

Název v anglickém jazyce

Lurcher Mouse

Popis výsledku anglicky

Lurcher mutant mice represent one of the frequently used mouse models of the olivocerebellar degeneration. It is caused by a mutation in the ?2 glutamate receptor subunit encoding gene. The gain of function mutation changes the receptor into a leaky membrane channel leading to chronic depolarization of the cells expressing the receptor. Heterozygous Lurcher mice suffer from virtually complete postnatal loss of cerebellar Purkinje cells and reduction of granule, stellate and basket cells and inferior olive neurons and relatively mild changes in the deep cerebellar nuclei. The death of Purkinje cells is a primary effect of the mutation and it shows features of apoptosis, autophagy and necrosis. Extinction of the granule, stellate and basket cells and inferior olive neurons is a target-related cell death. Lurcher mice display neurochemical and metabolic changes, abnormalities in the neurotransmitter and receptor systems, endocrine and immune abnormalities and multiple behavioral deficits.

Druh

C - Kapitola v odborné knize

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook of the Cerebellum and Cerebellar Disorders

ISBN

978-94-007-1333-8

Počet stran výsledku

22

Strana od-do

1499-1520

Počet stran knihy

2424

Název nakladatele

Springer New York LLC

Místo vydání

New York

Kód UT WoS kapitoly

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