Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10138982" target="_blank" >RIV/00216208:11140/13:10138982 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/13:10138982

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.artres.2012.11.002" target="_blank" >http://dx.doi.org/10.1016/j.artres.2012.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.artres.2012.11.002" target="_blank" >10.1016/j.artres.2012.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

Popis výsledku v původním jazyce

In a pilot study, we genotyped 101 untreated subjects (mean age, 54.0 years). Arterial properties were measured using SphygmoCor. We used robust multivariate analysis to assess whether rs3918226 was associated with peripheral or central blood pressure, carotidfemoral pulse wave velocity (PWV) and aortic augmentation index (AIx). As independent covariates we considered sex, age, MAP, heart rate and smoking. Results: Frequencies of rs3918226 genotypes were CC 85.2%, CT 14.8%, and TT 0%. Current smokers carrying mutated T allele had marginally higher PWV (10.0 0.8 vs. 8.7 0.4 m/s; P Z 0.051) and significantly higher AIx (172.2 6.8 vs. 153.2 3.8%; P Z 0.024) compared to CC homozygotes. In non-smokers we did not find any association between rs3918226 and arterial properties (P 0.62). Moreover, we did not observe any association between either peripheral or central blood pressure and the polymorphism under study (P 0.58). Conclusions: This is the first study to explore the association of rs3

Název v anglickém jazyce

Association between endothelial NO synthase polymorphism (rs3918226) and arterial properties

Popis výsledku anglicky

In a pilot study, we genotyped 101 untreated subjects (mean age, 54.0 years). Arterial properties were measured using SphygmoCor. We used robust multivariate analysis to assess whether rs3918226 was associated with peripheral or central blood pressure, carotidfemoral pulse wave velocity (PWV) and aortic augmentation index (AIx). As independent covariates we considered sex, age, MAP, heart rate and smoking. Results: Frequencies of rs3918226 genotypes were CC 85.2%, CT 14.8%, and TT 0%. Current smokers carrying mutated T allele had marginally higher PWV (10.0 0.8 vs. 8.7 0.4 m/s; P Z 0.051) and significantly higher AIx (172.2 6.8 vs. 153.2 3.8%; P Z 0.024) compared to CC homozygotes. In non-smokers we did not find any association between rs3918226 and arterial properties (P 0.62). Moreover, we did not observe any association between either peripheral or central blood pressure and the polymorphism under study (P 0.58). Conclusions: This is the first study to explore the association of rs3

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Artery Research

ISSN

1872-9312

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

54-59

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—