Association between endothelial NO synthase polymorphisms and arterial properties in the general population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10290175" target="_blank" >RIV/00216208:11140/15:10290175 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1089860314005060" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1089860314005060</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.niox.2014.11.016" target="_blank" >10.1016/j.niox.2014.11.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between endothelial NO synthase polymorphisms and arterial properties in the general population

Popis výsledku v původním jazyce

Objective Nitric oxide plays an important role in vascular biology. Several single nucleotide polymorphisms (SNP) in the endothelial nitric oxide gene (NOS3) have been previously associated with arterial hypertension. We investigated whether these SNPs might be associated with arterial phenotypes in the Czech general population. Methods We genotyped three NOS3 SNPs in 426 subjects not treated for arterial hypertension (mean age, 49.1 years; 55.9% women). Arterial properties were measured using applanation tonometry. In multivariate-adjusted analyses, we assessed the gene effects of rs3918226 (MINUS SIGN 665 C > T), rs1799983 (glu298asp G > T) and rs2070744 (786 T > C) on augmentation index (AIx), central augmentation pressure (AP) and aortic pulse wavevelocity (PWV). Results Carriers of rs3918226 mutated T allele had marginally higher AIx (145.3 +- 2.5 vs. 140.2 +- 1.1%; P = 0.064) and significantly higher AP (12.7 +- 0.7 vs. 11.1 +- 0.3 mm Hg; P = 0.033). These associations were inde

Název v anglickém jazyce

Association between endothelial NO synthase polymorphisms and arterial properties in the general population

Popis výsledku anglicky

Objective Nitric oxide plays an important role in vascular biology. Several single nucleotide polymorphisms (SNP) in the endothelial nitric oxide gene (NOS3) have been previously associated with arterial hypertension. We investigated whether these SNPs might be associated with arterial phenotypes in the Czech general population. Methods We genotyped three NOS3 SNPs in 426 subjects not treated for arterial hypertension (mean age, 49.1 years; 55.9% women). Arterial properties were measured using applanation tonometry. In multivariate-adjusted analyses, we assessed the gene effects of rs3918226 (MINUS SIGN 665 C > T), rs1799983 (glu298asp G > T) and rs2070744 (786 T > C) on augmentation index (AIx), central augmentation pressure (AP) and aortic pulse wavevelocity (PWV). Results Carriers of rs3918226 mutated T allele had marginally higher AIx (145.3 +- 2.5 vs. 140.2 +- 1.1%; P = 0.064) and significantly higher AP (12.7 +- 0.7 vs. 11.1 +- 0.3 mm Hg; P = 0.033). These associations were inde

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nitric Oxide - Biology and Chemistry

ISSN

1089-8603

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

47-51

Kód UT WoS článku

000348694800008

EID výsledku v databázi Scopus

2-s2.0-84916910778