Asociacní studie promotorových polymorfizmu v genu pro NOS3 s alergickými chorobami

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F06%3A00015624" target="_blank" >RIV/00216224:14110/06:00015624 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Association study of promoter polymorphisms within NOS3 gene with allergic diseases

Popis výsledku v původním jazyce

Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesised that polymorphisms in the NOS3 gene could be associated with the disease process.Two promoter variants (-786C/T and -691C/T)were examined in a Caucasian Czech population of allergic patients [n=671, with a subgroup of asthmatics (n=305)] and healthy controls (n=334) using PCR-RFLP analyses. NOS3 -786C/T and -691C/T were not associated with allergic diseases or asthma. However, the 786 variant was significantly associated with asthma in men (p &lt; 0.01, Pcorr &lt; 0.05) but not in women. NOS3 -691C/T was found to be in strong linkage disequilibrium with -786C/T, and the distribution of combined genotypes was marginally different between the asthmatic and control men. Our results suggest that NOS3 gene variants may be one of the factors that participate in the pathogenesis of asthma in men.

Název v anglickém jazyce

Association study of promoter polymorphisms within NOS3 gene with allergic diseases

Popis výsledku anglicky

Nitric oxide (NO) is an important mediator of physiologic and pathologic processes in the airways. On this basis, we hypothesised that polymorphisms in the NOS3 gene could be associated with the disease process.Two promoter variants (-786C/T and -691C/T)were examined in a Caucasian Czech population of allergic patients [n=671, with a subgroup of asthmatics (n=305)] and healthy controls (n=334) using PCR-RFLP analyses. NOS3 -786C/T and -691C/T were not associated with allergic diseases or asthma. However, the 786 variant was significantly associated with asthma in men (p &lt; 0.01, Pcorr &lt; 0.05) but not in women. NOS3 -691C/T was found to be in strong linkage disequilibrium with -786C/T, and the distribution of combined genotypes was marginally different between the asthmatic and control men. Our results suggest that NOS3 gene variants may be one of the factors that participate in the pathogenesis of asthma in men.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GP310%2F03%2FP045" target="_blank" >GP310/03/P045: Analýza polymorfizmů v genech pro syntetázu oxidu dusnatého (NOS) u atopického astmatu a jiných alergií v české populaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Archives of Allegy and Immunology

ISSN

ISSN 1018-243

e-ISSN

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Svazek periodika

141

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

103-109

Kód UT WoS článku

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EID výsledku v databázi Scopus

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