Prevalence of endothelial nitric oxide synthase gene polymorphisms in patients with atopic asthma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F02%3A00005702" target="_blank" >RIV/00216224:14110/02:00005702 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence of endothelial nitric oxide synthase gene polymorphisms in patients with atopic asthma

Popis výsledku v původním jazyce

Asthma is a common multifactorial disease, the etiology of which is attributable to both environmental and genetic factors. The endothelial nitric oxide synthase (NOS3) gene has been implicated in asthma pathogenesis.This study investigated associationsof 27 base-pair tandem repeat polymorphism in intron 4 and the Glu298Asp (G894T) variant of the NOS3 gene with atopic asthma in a Czech population. Polymerase chain reaction was used to determine the NOS3 genotypes in subjects with atopic asthma (n=163)and random controls (n=209). The NOS3 allele or genotype distributions did not significantly differ between the control and asthma groups. However, the common genotype (bb) of the NOS3 polymorphism in intron 4 was found to be significantly associated with total IgE levels (P=0.006), specific IgE levels for feathers (p=0.0002) and a positive skin prick test for hay (P=0.004). In one atopic patient, we identified an additional 27-bp repeat in the NOS3 gene (NOS3c), which occurred in hetero

Název v anglickém jazyce

Prevalence of endothelial nitric oxide synthase gene polymorphisms in patients with atopic asthma

Popis výsledku anglicky

Asthma is a common multifactorial disease, the etiology of which is attributable to both environmental and genetic factors. The endothelial nitric oxide synthase (NOS3) gene has been implicated in asthma pathogenesis.This study investigated associationsof 27 base-pair tandem repeat polymorphism in intron 4 and the Glu298Asp (G894T) variant of the NOS3 gene with atopic asthma in a Czech population. Polymerase chain reaction was used to determine the NOS3 genotypes in subjects with atopic asthma (n=163)and random controls (n=209). The NOS3 allele or genotype distributions did not significantly differ between the control and asthma groups. However, the common genotype (bb) of the NOS3 polymorphism in intron 4 was found to be significantly associated with total IgE levels (P=0.006), specific IgE levels for feathers (p=0.0002) and a positive skin prick test for hay (P=0.004). In one atopic patient, we identified an additional 27-bp repeat in the NOS3 gene (NOS3c), which occurred in hetero

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clin Exp Allergy

ISSN

0954-7894

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1193

Kód UT WoS článku

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EID výsledku v databázi Scopus

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