Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F13%3A10139601" target="_blank" >RIV/00216208:11140/13:10139601 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >http://dx.doi.org/10.1016/j.etap.2013.09.003</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2013.09.003" target="_blank" >10.1016/j.etap.2013.09.003</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats
Popis výsledku v původním jazyce
In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of ino
Název v anglickém jazyce
Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats
Popis výsledku anglicky
In this study, oxidative stress-related parameters and As retention were examined in liverand kidneys of male Wistar rats exposed to arsenic trioxide, sodium arsenite (iAsIII), sodiumarsenate (iAsV), and dimethylarsinic acid (DMAsV) at a single ip dose of 3.8 mg As/kg bw, at24 h post-exposure. In liver, lipid peroxidation increased in iAsIII-exposed rats, glutathioneperoxidase activity decreased in inorganic arsenic (iAs)-exposed rats, and catalase and thioredoxin reductase activities decreased significantly in all As-exposed groups. Both As(III) and As(V) exposure elevated GSH level with no effect on glutathione reductase activity. In kidneys, catalase activity decreased significantly in iAs-exposed, rats; GSH level, glutathione reductase and thioredoxin reductase activity decreased in DMAsV-treated, rats. The tissue As retention was higher in kidneys compared to liver and was also higher in As(III)-exposed compared to As(V)-exposed rats. The results demonstrate similar potency of ino
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Environmental Toxicology and Pharmacology
ISSN
1382-6689
e-ISSN
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Svazek periodika
36
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
1015-1021
Kód UT WoS článku
000329530600033
EID výsledku v databázi Scopus
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