Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10156021" target="_blank" >RIV/00216208:11140/14:10156021 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1214021X13000021#" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1214021X13000021#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2013.03.001" target="_blank" >10.1016/j.jab.2013.03.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Popis výsledku v původním jazyce

The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellarPurkinje cells and a secondary reduction of granule cells and inferior olive neuron number. The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice.

Název v anglickém jazyce

Fate of two types of cerebellar graft in wild type and cerebellar mutant mice

Popis výsledku anglicky

The possibility of regeneration in a damaged central nervous system (CNS) is limited and therapy of CNS diseases accompanied with neuronal loss is problematic. Neurotransplantation-based therapies have a great potential for future treatments of various diseases, not only by replacing missing or malfunctioning cells but mainly by supporting the inner regenerative processes. Lurcher (Lc) mutant mice represent a model for olivocerebellar degeneration. Heterozygotes suffer from a complete loss of cerebellarPurkinje cells and a secondary reduction of granule cells and inferior olive neuron number. The aim of this study was to analyze the survival potential and appearance of grafted GFP-positive carcinoma stem cells partially differentiated into neuroprogenitors from the P19 line or cerebellar embryonic tissue (in the form of cell suspension) both transplanted into the cerebellum of Lurcher mutant and healthy control wild type mice.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

17-23

Kód UT WoS článku

000333504400002

EID výsledku v databázi Scopus

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