The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F14%3A10159501" target="_blank" >RIV/00216208:11140/14:10159501 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0304394013009968/1-s2.0-S0304394013009968-main.pdf?_tid=0e04558e-67c7-11e3-8c6f-00000aab0f02&acdnat=1387359218_d15396f359a5d395760128caf32ef683" target="_blank" >http://ac.els-cdn.com/S0304394013009968/1-s2.0-S0304394013009968-main.pdf?_tid=0e04558e-67c7-11e3-8c6f-00000aab0f02&acdnat=1387359218_d15396f359a5d395760128caf32ef683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2013.11.005" target="_blank" >10.1016/j.neulet.2013.11.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration

Popis výsledku v původním jazyce

Sensory deprivation in one modality can enhance the development of the remaining modalities via mech-anisms of synaptic plasticity. Mice of the C3H strain suffer from RD1 retinal degeneration that leads tovisual impairment at weaning age. We examined a role of whiskers in compensation of the visual deficit.In order to differentiate the contribution of the whiskers from other mechanisms that can take part in thecompensation, we investigated the effect of both chronic and acute tactile deprivation. Three-month-oldmice were used. We examined motor skills (rotarod, beam walking test), gait control (CatWalk system),spontaneous motor activity (open field) and CNS excitability to an acoustic stimulus for assessment ofcompensatory changes in auditory system (audiogenic epilepsy). In the sighted mice, the only effect was adecline in their rotarod test performance after acute whisker removal. In the blind animals, chronic tactiledeprivation caused changes in their gait and impaired the performan

Název v anglickém jazyce

The role of whiskers in compensation of visual deficit in a mouse model of retinal degeneration

Popis výsledku anglicky

Sensory deprivation in one modality can enhance the development of the remaining modalities via mech-anisms of synaptic plasticity. Mice of the C3H strain suffer from RD1 retinal degeneration that leads tovisual impairment at weaning age. We examined a role of whiskers in compensation of the visual deficit.In order to differentiate the contribution of the whiskers from other mechanisms that can take part in thecompensation, we investigated the effect of both chronic and acute tactile deprivation. Three-month-oldmice were used. We examined motor skills (rotarod, beam walking test), gait control (CatWalk system),spontaneous motor activity (open field) and CNS excitability to an acoustic stimulus for assessment ofcompensatory changes in auditory system (audiogenic epilepsy). In the sighted mice, the only effect was adecline in their rotarod test performance after acute whisker removal. In the blind animals, chronic tactiledeprivation caused changes in their gait and impaired the performan

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/ED2.1.00%2F03.0076" target="_blank" >ED2.1.00/03.0076: Biomedicínské centrum Lékařské fakulty v Plzni</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

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Svazek periodika

558

Číslo periodika v rámci svazku

January

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

149-153

Kód UT WoS článku

000338481300028

EID výsledku v databázi Scopus

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