Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10292610" target="_blank" >RIV/00216208:11140/15:10292610 - isvavai.cz</a>

Výsledek na webu

<a href="http://jjbs.hu.edu.jo/files/v8n1/Paper%20Number%203m.pdf" target="_blank" >http://jjbs.hu.edu.jo/files/v8n1/Paper%20Number%203m.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Popis výsledku v původním jazyce

Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility. The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women. We focus on the distribution of serum seminal/sperm-specific antibodies in order to find those apparently related to female isoimmunization. Immunoglobulins G1-4, A1,2, M and E were measured by ELISA in serum from 30 infertile and 10 fertile females. Anti-seminal/sperm IgG1 and IgG4 fractions were predominantly detected. Anti-seminal IgG1 and IgG4 were observed approximately in the 2:1 ratio, anti-sperm fraction in the 1:2 ratio. Strikingly, the approximate ratio between IgG1 and IgG2 was 3:1 in seminal specific and 2:1 in sperm specific antibodies. Surprisingly, IgG3 antibodies were nearly negative for both antigen fractions, seminal and sperm. Concerning our results, the proportionality does exist between seminal and sperm antibody fractions. Based on the

Název v anglickém jazyce

Immunodominant Semen Proteins III: IgG1 and IgG4 Linkage in Female Immune Infertility

Popis výsledku anglicky

Generated antibodies in the process of isoimmunization seem to be associated with female immune infertility. The aim of our study consists in the profiling of specific serum immunoglobulin classes and subclasses in infertile women. We focus on the distribution of serum seminal/sperm-specific antibodies in order to find those apparently related to female isoimmunization. Immunoglobulins G1-4, A1,2, M and E were measured by ELISA in serum from 30 infertile and 10 fertile females. Anti-seminal/sperm IgG1 and IgG4 fractions were predominantly detected. Anti-seminal IgG1 and IgG4 were observed approximately in the 2:1 ratio, anti-sperm fraction in the 1:2 ratio. Strikingly, the approximate ratio between IgG1 and IgG2 was 3:1 in seminal specific and 2:1 in sperm specific antibodies. Surprisingly, IgG3 antibodies were nearly negative for both antigen fractions, seminal and sperm. Concerning our results, the proportionality does exist between seminal and sperm antibody fractions. Based on the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Jordan Journal of Biological Sciences

ISSN

1995-6673

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

JO - Jordánské hášimovské království

Počet stran výsledku

5

Strana od-do

17-21

Kód UT WoS článku

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EID výsledku v databázi Scopus

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