Assessment of Grading in Newly-diagnosed Glioma Using 18F-Fluorothymidine PET/CT

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F15%3A10293632" target="_blank" >RIV/00216208:11140/15:10293632 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/15:10293632

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of Grading in Newly-diagnosed Glioma Using 18F-Fluorothymidine PET/CT

Popis výsledku v původním jazyce

Aim: To evaluate the proliferation activity in gliomas using 18F-fluorothymidine (18F-FLT)-positron emission tomography/computed tomography (PET/CT). Patients and Methods: Samples of 26 tumors were analyzed (mean age=51.6; range=26-72 years; 16 males, 10females). All examinations were performed using a PET/CT scanner equipped with lutetium oxyorthosilicate (LSO) detectors. All data were acquired with a delay of 15 min, following intravenous application of 18F-FLT (dosed 2 MBq/kg of body weight). The PET/CT contained CT after intravenous application of iodinated contrast agent and high-resolution brain PET acquired during 15 min in one position. PET/CT was performed before confirmation of the histological diagnosis and the level of 18F-FLT accumulationwas compared to the grading of the tumor evaluated using immunohistochemistry staining of Ki-67. Samples were obtained by stereotactic biopsy (5x) or surgical resection (21x). Results: Five tumors of grade IV, 7 tumors of grade III and 1

Název v anglickém jazyce

Assessment of Grading in Newly-diagnosed Glioma Using 18F-Fluorothymidine PET/CT

Popis výsledku anglicky

Aim: To evaluate the proliferation activity in gliomas using 18F-fluorothymidine (18F-FLT)-positron emission tomography/computed tomography (PET/CT). Patients and Methods: Samples of 26 tumors were analyzed (mean age=51.6; range=26-72 years; 16 males, 10females). All examinations were performed using a PET/CT scanner equipped with lutetium oxyorthosilicate (LSO) detectors. All data were acquired with a delay of 15 min, following intravenous application of 18F-FLT (dosed 2 MBq/kg of body weight). The PET/CT contained CT after intravenous application of iodinated contrast agent and high-resolution brain PET acquired during 15 min in one position. PET/CT was performed before confirmation of the histological diagnosis and the level of 18F-FLT accumulationwas compared to the grading of the tumor evaluated using immunohistochemistry staining of Ki-67. Samples were obtained by stereotactic biopsy (5x) or surgical resection (21x). Results: Five tumors of grade IV, 7 tumors of grade III and 1

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

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Svazek periodika

35

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

955-959

Kód UT WoS článku

000349598600044

EID výsledku v databázi Scopus

2-s2.0-84923673739