Gasotransmitters in gametogenesis and early development: Holy Trinity for Assisted Reproductive Technology. A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10324444" target="_blank" >RIV/00216208:11140/16:10324444 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2016/1730750" target="_blank" >http://dx.doi.org/10.1155/2016/1730750</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2016/1730750" target="_blank" >10.1155/2016/1730750</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gasotransmitters in gametogenesis and early development: Holy Trinity for Assisted Reproductive Technology. A Review

Popis výsledku v původním jazyce

Creation of both gametes, sperm and oocyte, and their fusion during fertilization, are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization and early embryonic development are still subjected to intensive study, a lot of phenomena remains unclear. Based on our best knowledge and own results, we consider gastoransmitters to be esential or various signalisation in oocytes and embryos. In accordance to nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO- and H2S-derived post-translational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.

Název v anglickém jazyce

Gasotransmitters in gametogenesis and early development: Holy Trinity for Assisted Reproductive Technology. A Review

Popis výsledku anglicky

Creation of both gametes, sperm and oocyte, and their fusion during fertilization, are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization and early embryonic development are still subjected to intensive study, a lot of phenomena remains unclear. Based on our best knowledge and own results, we consider gastoransmitters to be esential or various signalisation in oocytes and embryos. In accordance to nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO- and H2S-derived post-translational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oxidative Medicine and Cellular Longevity

ISSN

1942-0900

e-ISSN

—

Svazek periodika

Neuveden

Číslo periodika v rámci svazku

august

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

—

Kód UT WoS článku

000382048000001

EID výsledku v databázi Scopus

2-s2.0-84984674617