Key Features of Genomic Imprinting during Mammalian Spermatogenesis: Perspectives for Human assisted Reproductive Therapy: A Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10327597" target="_blank" >RIV/00216208:11140/16:10327597 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.4172/2161-0940.1000236" target="_blank" >http://dx.doi.org/10.4172/2161-0940.1000236</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4172/2161-0940.1000236" target="_blank" >10.4172/2161-0940.1000236</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Key Features of Genomic Imprinting during Mammalian Spermatogenesis: Perspectives for Human assisted Reproductive Therapy: A Review

Popis výsledku v původním jazyce

Increasing influence of epigenetics is obvious in all medical fields including reproductive medicine. Epigenetic alterations of the genome and associated post-translational modifications of DNA binding histones equally impact gamete development and maturation, as well as embryogenesis. Relationships between methylation and acetylation of histones and involvement of DNA methylation are important not only for chromatin remodelling but also significant to gene imprinting and thus affecting the gene expression in the embryo. Therefore, gene silencing accompanied with methylation of histones and DNA is a result of heterochromatin establishment in haploid male germ cell, the spermatid. Complex epigenetic changes leading to the establishment of histone code and heterochromatin are regulated by a broad range of factors, such as histone deacetylases, histone methyltransferases, non-coding RNAs, and small protein modifiers ubiquitin and SUMO. These factors are candidate diagnostic targets for reproductive medicine when anomalous gene imprinting or histone modification of the gametes may disrupt embryo development or cause developmental disorders in the offspring. Using advanced non-invasive techniques for sperm selection based on testing of epigenetic markers is a possible approach to more successful assisted reproductive therapy (ART) as well as prevention of epigenetic-origin disorders in ART babies.

Název v anglickém jazyce

Key Features of Genomic Imprinting during Mammalian Spermatogenesis: Perspectives for Human assisted Reproductive Therapy: A Review

Popis výsledku anglicky

Increasing influence of epigenetics is obvious in all medical fields including reproductive medicine. Epigenetic alterations of the genome and associated post-translational modifications of DNA binding histones equally impact gamete development and maturation, as well as embryogenesis. Relationships between methylation and acetylation of histones and involvement of DNA methylation are important not only for chromatin remodelling but also significant to gene imprinting and thus affecting the gene expression in the embryo. Therefore, gene silencing accompanied with methylation of histones and DNA is a result of heterochromatin establishment in haploid male germ cell, the spermatid. Complex epigenetic changes leading to the establishment of histone code and heterochromatin are regulated by a broad range of factors, such as histone deacetylases, histone methyltransferases, non-coding RNAs, and small protein modifiers ubiquitin and SUMO. These factors are candidate diagnostic targets for reproductive medicine when anomalous gene imprinting or histone modification of the gametes may disrupt embryo development or cause developmental disorders in the offspring. Using advanced non-invasive techniques for sperm selection based on testing of epigenetic markers is a possible approach to more successful assisted reproductive therapy (ART) as well as prevention of epigenetic-origin disorders in ART babies.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anatomy &amp; Physiology: Current Research

ISSN

2161-0940

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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