Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F17%3A67960" target="_blank" >RIV/60460709:41210/17:67960 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development

Popis výsledku v původním jazyce

In vitro fertilization (IVF) and embryo culture is a key approach for study of early development in mammals, with application in human assisted reproductive therapy (ART) and livestock embryo transfer (ET). Persistent issue of current assisted reproduction is decreased efficiency of embryo production compared to in vivo conditions. Beside DNA methylation, adequate insertion and post-translational modifications of DNA-associated histones determine zygote genome stability, parental gene expression inheritance and proper formation of zygotic pronuclei and blastomere nuclei. Subsequent to the formation of maternal and paternal pronuclei, the timing of nucleolus reconstitution and reactivation, and embryonic genome reprogramming is species specific. Such DNA and histone modifications during early development are regulated by ooplasmic factors including DNA methyltransferases, histone methyltransferases and histone deacetylases, as well as by the ubiquitin-proteasome system (UPS), a significant epigenome c

Název v anglickém jazyce

Epigenome Modification and Ubiquitin-Dependent Proteolysis During Pronuclear Development of the Mammalian Zygote: Animal Models to Study Pronuclear Development

Popis výsledku anglicky

In vitro fertilization (IVF) and embryo culture is a key approach for study of early development in mammals, with application in human assisted reproductive therapy (ART) and livestock embryo transfer (ET). Persistent issue of current assisted reproduction is decreased efficiency of embryo production compared to in vivo conditions. Beside DNA methylation, adequate insertion and post-translational modifications of DNA-associated histones determine zygote genome stability, parental gene expression inheritance and proper formation of zygotic pronuclei and blastomere nuclei. Subsequent to the formation of maternal and paternal pronuclei, the timing of nucleolus reconstitution and reactivation, and embryonic genome reprogramming is species specific. Such DNA and histone modifications during early development are regulated by ooplasmic factors including DNA methyltransferases, histone methyltransferases and histone deacetylases, as well as by the ubiquitin-proteasome system (UPS), a significant epigenome c

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10604 - Reproductive biology (medical aspects to be 3)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction

ISBN

9781118881422

Počet stran výsledku

16

Strana od-do

435-450

Počet stran knihy

600

Název nakladatele

Willey & Sons

Místo vydání

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Kód UT WoS kapitoly

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