Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10329877" target="_blank" >RIV/00216208:11140/16:10329877 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs00428-016-2018-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs00428-016-2018-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00428-016-2018-6" target="_blank" >10.1007/s00428-016-2018-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

Popis výsledku v původním jazyce

Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteriahavenotbeenuniversallyagreedupon.Incontrast,the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and thenumberofreportedcasesisrapidlyincreasing.Areviewof the literature revealed 38 cases of hybrid tumour reported in 22 publications. During approximately the same time period, well over 100 cases of HGT in salivary neoplasms have been reported.Thereareimportanthistologicalsimilaritiesbetween hybrid tumours and salivary tumours with HGT. In the latter, containing one tumour component of low-grade malignancy and the other of high grade, the two tumour components are notentirelyseparatedandappeartooriginateinthesamearea. Virtually, all cases reported as hybrid tumour had no clear lines of demarcation between the two tumour types. We are inclinedtosuggestthatmostofthe38casesofhybridtumours describedintheliteraturewouldtodaybetterbecalledtumour with HGT rather than hybrid tumour. The relative proportion of the two components may vary, and the high-grade component is sometimes very small, which emphasises the importanceofverygeneroussamplingofthesurgicalspecimen.The molecular genetic mechanisms responsible for HGT, including what used to be called hybrid tumour, remain largely unknown.Abnormalitiesofafewgenes(includingp53,C-MYC, cyclinD1,HER-2/neu)havebeendocumented.Asinsufficient data exist on gene abnormalities in these lesions, conclusions as to whether or not they have a common origin and which mechanisms are involved in transformation cannot be drawn. Due to the small number of cases reported, many of which lack follow-up details; indicators of prognosis of hybrid tumours are not available, but their behaviour seems to be similartothatoftumourswithHGT,i.e.anacceleratedaggressive course.

Název v anglickém jazyce

Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

Popis výsledku anglicky

Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteriahavenotbeenuniversallyagreedupon.Incontrast,the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and thenumberofreportedcasesisrapidlyincreasing.Areviewof the literature revealed 38 cases of hybrid tumour reported in 22 publications. During approximately the same time period, well over 100 cases of HGT in salivary neoplasms have been reported.Thereareimportanthistologicalsimilaritiesbetween hybrid tumours and salivary tumours with HGT. In the latter, containing one tumour component of low-grade malignancy and the other of high grade, the two tumour components are notentirelyseparatedandappeartooriginateinthesamearea. Virtually, all cases reported as hybrid tumour had no clear lines of demarcation between the two tumour types. We are inclinedtosuggestthatmostofthe38casesofhybridtumours describedintheliteraturewouldtodaybetterbecalledtumour with HGT rather than hybrid tumour. The relative proportion of the two components may vary, and the high-grade component is sometimes very small, which emphasises the importanceofverygeneroussamplingofthesurgicalspecimen.The molecular genetic mechanisms responsible for HGT, including what used to be called hybrid tumour, remain largely unknown.Abnormalitiesofafewgenes(includingp53,C-MYC, cyclinD1,HER-2/neu)havebeendocumented.Asinsufficient data exist on gene abnormalities in these lesions, conclusions as to whether or not they have a common origin and which mechanisms are involved in transformation cannot be drawn. Due to the small number of cases reported, many of which lack follow-up details; indicators of prognosis of hybrid tumours are not available, but their behaviour seems to be similartothatoftumourswithHGT,i.e.anacceleratedaggressive course.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virchows Archiv : an international journal of pathology

ISSN

0945-6317

e-ISSN

—

Svazek periodika

469

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

643-650

Kód UT WoS článku

000389207700006

EID výsledku v databázi Scopus

2-s2.0-84986302078