Postmenopausal breast cancer: European challenge and innovative concepts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10360351" target="_blank" >RIV/00216208:11140/17:10360351 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/17:10360351

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s13167-017-0094-6" target="_blank" >https://link.springer.com/article/10.1007/s13167-017-0094-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13167-017-0094-6" target="_blank" >10.1007/s13167-017-0094-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Postmenopausal breast cancer: European challenge and innovative concepts

Popis výsledku v původním jazyce

Breast cancer (BC) epidemic is recognised now worldwide as the reality of the early twenty-first century. Increasing trends in the postmenopausal BC prevalence, even for the European countries earlier demonstrating relatively stable incidence rates of the disease, are highly alarming for the healthcare givers. This new actuality requires a substantial revision of the paradigm currently applied to the BC management and creation of highly innovative concepts. Current multi-centred study highlights new complex mechanisms of the development and progression of the postmenopausal BC. Innovative concepts are presented which argue for more effective predictive and preventive approaches well justified in view of the clusters of the symptoms analysed here and demonstrated as highly prevalent in the postmenopausal breast cancer versus BC-free individuals. Another conceptual novelty presented here is a new interpretation of the BSeed and Soil^ theory of metastasis in BC. According to the new concept, the Bpre-metastatic niches^ (BSoil^) are created by a systemic hypoxia a long time before the breast malignancy is clinically manifested.

Název v anglickém jazyce

Postmenopausal breast cancer: European challenge and innovative concepts

Popis výsledku anglicky

Breast cancer (BC) epidemic is recognised now worldwide as the reality of the early twenty-first century. Increasing trends in the postmenopausal BC prevalence, even for the European countries earlier demonstrating relatively stable incidence rates of the disease, are highly alarming for the healthcare givers. This new actuality requires a substantial revision of the paradigm currently applied to the BC management and creation of highly innovative concepts. Current multi-centred study highlights new complex mechanisms of the development and progression of the postmenopausal BC. Innovative concepts are presented which argue for more effective predictive and preventive approaches well justified in view of the clusters of the symptoms analysed here and demonstrated as highly prevalent in the postmenopausal breast cancer versus BC-free individuals. Another conceptual novelty presented here is a new interpretation of the BSeed and Soil^ theory of metastasis in BC. According to the new concept, the Bpre-metastatic niches^ (BSoil^) are created by a systemic hypoxia a long time before the breast malignancy is clinically manifested.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EPMA Journal

ISSN

1878-5077

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

159-169

Kód UT WoS článku

000405833600007

EID výsledku v databázi Scopus

2-s2.0-85020694775