PET/MRI: Multiparametric imaging of brain tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F17%3A10363641" target="_blank" >RIV/00216208:11140/17:10363641 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/17:10363641

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0720048X17300864?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0720048X17300864?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejrad.2017.02.034" target="_blank" >10.1016/j.ejrad.2017.02.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PET/MRI: Multiparametric imaging of brain tumors

Popis výsledku v původním jazyce

A combination of morphological imaging of the brain with microstructural and functional imaging pro- vides a comprehensive overview of the properties of individual tissues. While diffusion weighted imaging provides information about tissue cellularity, spectroscopic imaging allows us to evaluate the integrity of neurons and possible anaerobic glycolysis during tumor hypoxia, in addition to the presence of accel- erated synthesis or degradation of cellular membranes; on the other hand, PET metabolic imaging is used to evaluate major metabolic pathways, determining the overall extent of the tumor ( 18 F-FET, 18 F-FDOPA, 18 F-FCH) or the degree of differentiation ( 18 F-FDG, 18 F-FLT, 18 F-FDOPA and 18 F-FET). Multi-parameter analysis of tissue characteristics and determination of the phenotype of the tumor tissue is a natural advantage of PET/MRI scanning. The disadvantages are higher cost and limited availability in all centers with neuro-oncology surgery. PET/MRI scanning of brain tumors is one of the most promising indications since the earliest experiments with integrated PET/MRI imaging systems, and along with hybrid imaging of neurodegenerative diseases, represent a new direction in the development of neuroradiology on the path towards comprehensive imaging at the molecular level.

Název v anglickém jazyce

PET/MRI: Multiparametric imaging of brain tumors

Popis výsledku anglicky

A combination of morphological imaging of the brain with microstructural and functional imaging pro- vides a comprehensive overview of the properties of individual tissues. While diffusion weighted imaging provides information about tissue cellularity, spectroscopic imaging allows us to evaluate the integrity of neurons and possible anaerobic glycolysis during tumor hypoxia, in addition to the presence of accel- erated synthesis or degradation of cellular membranes; on the other hand, PET metabolic imaging is used to evaluate major metabolic pathways, determining the overall extent of the tumor ( 18 F-FET, 18 F-FDOPA, 18 F-FCH) or the degree of differentiation ( 18 F-FDG, 18 F-FLT, 18 F-FDOPA and 18 F-FET). Multi-parameter analysis of tissue characteristics and determination of the phenotype of the tumor tissue is a natural advantage of PET/MRI scanning. The disadvantages are higher cost and limited availability in all centers with neuro-oncology surgery. PET/MRI scanning of brain tumors is one of the most promising indications since the earliest experiments with integrated PET/MRI imaging systems, and along with hybrid imaging of neurodegenerative diseases, represent a new direction in the development of neuroradiology on the path towards comprehensive imaging at the molecular level.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Radiology

ISSN

0720-048X

e-ISSN

—

Svazek periodika

94

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

12

Strana od-do

"A14"-"A25"

Kód UT WoS článku

000411459400003

EID výsledku v databázi Scopus

2-s2.0-85014730344