The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F22%3A10448690" target="_blank" >RIV/00669806:_____/22:10448690 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/22:10448690

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9ihiUemeDj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9ihiUemeDj</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejrad.2022.110458" target="_blank" >10.1016/j.ejrad.2022.110458</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI

Popis výsledku v původním jazyce

Tissue hypoxia becomes the driver of the micro-environmental transformation of the malignant tumorous tissue in majority of solid tumors. Even more, during the development of solid tumors, a large amount of nutrients is consumed due to rapid proliferation of tumor cells. The way of use of nutrients could be assessed using the probes during positron emission tomography (PET), the most frequent is the use of F-18-fluorodeoxyglucose (F-18-FDG) demonstrating the turn-over of glucose exploitation in a manner of Warburg phenomenon. Even tumor cells can undergo metabolic reprogramming by changing the expression of glycolysis-related proteins, development of hypoxic condition increases glucose uptake to promote their growth. The hypoxic conditions are stimulation also the development of drug and/or radiation resistance, thus, the identification of the hypoxic tissue could play an important role in therapy planning. The process that enables use of hypoxia specific PET radiopharmaceutical starts when it enters cell by passive diffusion. Intracellularly, a model substance -F-18-fluoromisonidazol (F-18-FMISO) is reduced by nitroreductase enzymes to become trapped in cells within reduced tissue oxygen partial pressure. The identification of the hypoxic tissue aids to plan the target to radiotherapy in squamous cell car-cinomas of head and neck or cervical carcinoma, when F-18-FMISO-PET/CT is used as a planning procedure for a target volume, while F-18-FDG-PET/MRI is being the local and whole body staging procedure. Hypoxia imaging helps to identify the high-grade component of an astrocytic tumor before stereotactic biopsy. &lt;comment&gt;Superscript/Subscript Available&lt;/comment

Název v anglickém jazyce

The imaging of the hypoxic microenvironment in tumorous tissue using PET/CT and PET/MRI

Popis výsledku anglicky

Tissue hypoxia becomes the driver of the micro-environmental transformation of the malignant tumorous tissue in majority of solid tumors. Even more, during the development of solid tumors, a large amount of nutrients is consumed due to rapid proliferation of tumor cells. The way of use of nutrients could be assessed using the probes during positron emission tomography (PET), the most frequent is the use of F-18-fluorodeoxyglucose (F-18-FDG) demonstrating the turn-over of glucose exploitation in a manner of Warburg phenomenon. Even tumor cells can undergo metabolic reprogramming by changing the expression of glycolysis-related proteins, development of hypoxic condition increases glucose uptake to promote their growth. The hypoxic conditions are stimulation also the development of drug and/or radiation resistance, thus, the identification of the hypoxic tissue could play an important role in therapy planning. The process that enables use of hypoxia specific PET radiopharmaceutical starts when it enters cell by passive diffusion. Intracellularly, a model substance -F-18-fluoromisonidazol (F-18-FMISO) is reduced by nitroreductase enzymes to become trapped in cells within reduced tissue oxygen partial pressure. The identification of the hypoxic tissue aids to plan the target to radiotherapy in squamous cell car-cinomas of head and neck or cervical carcinoma, when F-18-FMISO-PET/CT is used as a planning procedure for a target volume, while F-18-FDG-PET/MRI is being the local and whole body staging procedure. Hypoxia imaging helps to identify the high-grade component of an astrocytic tumor before stereotactic biopsy. &lt;comment&gt;Superscript/Subscript Available&lt;/comment

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Radiology

ISSN

0720-048X

e-ISSN

1872-7727

Svazek periodika

154

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

110458

Kód UT WoS článku

000859871900001

EID výsledku v databázi Scopus

2-s2.0-85135407256