High-sensitivity troponins after a standardized 2-hour treadmill run

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10377150" target="_blank" >RIV/00216208:11140/18:10377150 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10377150

Výsledek na webu

<a href="https://doi.org/10.1515/jomb-2017-0055" target="_blank" >https://doi.org/10.1515/jomb-2017-0055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/jomb-2017-0055" target="_blank" >10.1515/jomb-2017-0055</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High-sensitivity troponins after a standardized 2-hour treadmill run

Popis výsledku v původním jazyce

Background: The aim of this study was to examine high-sensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. Methods: Nineteen trained men underwent a standardized 2-hour-long treadmill run. Concentrations of hsTnT and hsTnI were assessed before the run, 60, 120 and 180 minutes after the start and 24 hours after the run. Changes in troponins were tested using non-parametric analysis of variance (ANOVA). The multiple linear regression model was used to find the explanatory variables for hsTnT and hsTnI changes. Values of troponins were evaluated using the 0h/1h algorithm. Results: Changes in hsTnT and hsTnI levels were statistically significant (p &lt;0.0001 and p&lt;0.0001, respectively). In a multiple regression model (adjusted R-2: 0.60, p=0.005 for hsTnT and adjusted R-2: 0.60, p=0.005 for hsTnI), changes in both troponins can be explained by relative left wall thickness (LV), training volume, body temperature after the run and creatinine changes. According to the 0h/1h algorithm, none of the runners was evaluated as negative. Conclusions: Relative LV wall thickness, creatinine changes, training volume and body temperature after the run can predict changes in hsTnT and hsTnI levels. When medical attention is needed after physical exercise, hsTn levels should be tested only when clinical suspicion and the patient&apos;s history indicate a high probability of myocardial damage.

Název v anglickém jazyce

High-sensitivity troponins after a standardized 2-hour treadmill run

Popis výsledku anglicky

Background: The aim of this study was to examine high-sensitivity troponin T and I (hsTnT and hsTnI) after a treadmill run under laboratory conditions and to find a possible connection with echocardiographic, laboratory and other assessed parameters. Methods: Nineteen trained men underwent a standardized 2-hour-long treadmill run. Concentrations of hsTnT and hsTnI were assessed before the run, 60, 120 and 180 minutes after the start and 24 hours after the run. Changes in troponins were tested using non-parametric analysis of variance (ANOVA). The multiple linear regression model was used to find the explanatory variables for hsTnT and hsTnI changes. Values of troponins were evaluated using the 0h/1h algorithm. Results: Changes in hsTnT and hsTnI levels were statistically significant (p &lt;0.0001 and p&lt;0.0001, respectively). In a multiple regression model (adjusted R-2: 0.60, p=0.005 for hsTnT and adjusted R-2: 0.60, p=0.005 for hsTnI), changes in both troponins can be explained by relative left wall thickness (LV), training volume, body temperature after the run and creatinine changes. According to the 0h/1h algorithm, none of the runners was evaluated as negative. Conclusions: Relative LV wall thickness, creatinine changes, training volume and body temperature after the run can predict changes in hsTnT and hsTnI levels. When medical attention is needed after physical exercise, hsTn levels should be tested only when clinical suspicion and the patient&apos;s history indicate a high probability of myocardial damage.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medical Biochemistry

ISSN

1452-8258

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

RS - Srbská republika

Počet stran výsledku

9

Strana od-do

364-372

Kód UT WoS článku

000439420700011

EID výsledku v databázi Scopus

2-s2.0-85045846975