Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F22%3A10449430" target="_blank" >RIV/00216208:11150/22:10449430 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00179906:_____/22:10449430 RIV/00216224:14110/22:00128278

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ttoTGG2TQe" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=ttoTGG2TQe</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/echo.15411" target="_blank" >10.1111/echo.15411</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study

Popis výsledku v původním jazyce

Objectives: In stress echocardiography (SE), dipyridamole (DIP) and dynamic stress (ExSE) are reported as being safer than dobutamine stress echocardiography (DSE). We investigated whether these commonly used stressors cause myocardial injury, measured by high sensitivity troponin T (hsTnT). Methods: One hundred and thirty five patients (DSE n = 46, ExsE n = 46, DIP n = 43) with negative result of SE were studied. The exclusion criteria were known ischaemic heart disease (IHD), baseline wall motion abnormalities, left ventricle systolic dysfunction/regional wall motion abnormalities, septum/posterior wall &gt;= 13 mm, diabetes/pre-diabetes, baseline hsTnT level &gt;= 14 ng/L, baseline blood pressure &gt;= 160/100 mmHg, peak pulmonary pressure &gt;= 45mmHg, eGFR &lt;1ml/s/1.73m(2), more than mild to moderate valvular disease and dobutamine side effects. HsTnT was measured before and 180 minutes after the test. Results: All patients had low pre-test probabilities of having obstructive IHD. HsTnT increased in DSE, less so in ExSE, and was unchanged in the DIP group (Delta hsTnT 9.4 [1.5-58.6], 1.1 [-0.9-15.7], -0.1 [-1.4-2.1] ng/L, respectively, p&lt;0.001). In DSE, the Delta hsTnT was associated with peak dobutamine dose (r = 0.30, p = 0.045), test length (r = 0.43, p = 0.003) and atropine use (p&lt;0.001). In ExSE, the hsTnT increase was more likely in females (p = 0.012) and the elderly (&gt;65 years) (r = 0.32, p = 0.03); no association was found between atropine use (p = 0.786) or test length and AhsTnT (r = 0.10, p = 0.530). Conclusions: DSE is associated with myocardial injury in patients with negative SE, no injury was observed in DIP and only mild case in ExSE. Whether myocardial injury is causative of the higher reported adverse event rates in DSE remains to be determined.

Název v anglickém jazyce

Myocardial injury in stress echocardiography: Comparison of dobutamine, dipyridamole and dynamic stressors-single center study

Popis výsledku anglicky

Objectives: In stress echocardiography (SE), dipyridamole (DIP) and dynamic stress (ExSE) are reported as being safer than dobutamine stress echocardiography (DSE). We investigated whether these commonly used stressors cause myocardial injury, measured by high sensitivity troponin T (hsTnT). Methods: One hundred and thirty five patients (DSE n = 46, ExsE n = 46, DIP n = 43) with negative result of SE were studied. The exclusion criteria were known ischaemic heart disease (IHD), baseline wall motion abnormalities, left ventricle systolic dysfunction/regional wall motion abnormalities, septum/posterior wall &gt;= 13 mm, diabetes/pre-diabetes, baseline hsTnT level &gt;= 14 ng/L, baseline blood pressure &gt;= 160/100 mmHg, peak pulmonary pressure &gt;= 45mmHg, eGFR &lt;1ml/s/1.73m(2), more than mild to moderate valvular disease and dobutamine side effects. HsTnT was measured before and 180 minutes after the test. Results: All patients had low pre-test probabilities of having obstructive IHD. HsTnT increased in DSE, less so in ExSE, and was unchanged in the DIP group (Delta hsTnT 9.4 [1.5-58.6], 1.1 [-0.9-15.7], -0.1 [-1.4-2.1] ng/L, respectively, p&lt;0.001). In DSE, the Delta hsTnT was associated with peak dobutamine dose (r = 0.30, p = 0.045), test length (r = 0.43, p = 0.003) and atropine use (p&lt;0.001). In ExSE, the hsTnT increase was more likely in females (p = 0.012) and the elderly (&gt;65 years) (r = 0.32, p = 0.03); no association was found between atropine use (p = 0.786) or test length and AhsTnT (r = 0.10, p = 0.530). Conclusions: DSE is associated with myocardial injury in patients with negative SE, no injury was observed in DIP and only mild case in ExSE. Whether myocardial injury is causative of the higher reported adverse event rates in DSE remains to be determined.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Echocardiography

ISSN

0742-2822

e-ISSN

1540-8175

Svazek periodika

39

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1171-1179

Kód UT WoS článku

000838624800001

EID výsledku v databázi Scopus

2-s2.0-85135837175