Clinical impact and predictors of periprocedural myocardial injury among patients undergoing left bundle branch area pacing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064173%3A_____%2F24%3A43927302" target="_blank" >RIV/00064173:_____/24:43927302 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43927302 RIV/00216208:11150/24:10481742 RIV/00179906:_____/24:10481742

Výsledek na webu

<a href="https://doi.org/10.1007/s10840-024-01863-2" target="_blank" >https://doi.org/10.1007/s10840-024-01863-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10840-024-01863-2" target="_blank" >10.1007/s10840-024-01863-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical impact and predictors of periprocedural myocardial injury among patients undergoing left bundle branch area pacing

Popis výsledku v původním jazyce

BACKGROUND: The clinical impact of Periprocedural myocardial injury (PMI) in patients undergoing permanent pacemaker implantation with Left Bundle Branch Area Pacing (LBBAP) is unknown. METHODS: 130 patients undergoing LBBAP from January 2020 to June 2021 and completing 12 months follow up were enrolled to assess the impact of PMI on composite clinical outcome (CCO) defined as any of the following: all-cause death, hospitalization for heart failure (HHF), hospitalization for acute coronary syndrome (ACS) and ventricular arrhythmias (VAs). High sensitivity Troponin T (HsTnT) was measured up to 24-h after intervention to identify the peak HsTnT values. PMI was defined as increased peak HsTnT values at least &gt; 99th percentile of the upper reference limit (URL: 15 pg/ml) in patients with normal baseline values. RESULTS: PMI occurred in 72 of 130 patients (55%). ROC analysis yielded a post-procedural peak HsTnT cutoff of fourfold the URL for predicting the CCO (AUC: 0.692; p = 0.023; sensitivity 73% and specificity 71%). Of the enrolled patients, 20% (n = 26) had peak HsTnT &gt; fourfold the URL. Patients with peak HsTnT &gt; fourfold the URL exhibited a higher incidence of the CCO than patients with peak HsTnT &lt;= fourfold the URL (31% vs. 10%; p = 0.005), driven by more frequent hospitalizations for ACS (15% vs. 3%; p = 0.010). Multiple (&gt; 2) lead repositions attempts, the use of septography and stylet-driven leads were independent predictors of higher risk of PMI with peak HsTnT &gt; fourfold the URL. CONCLUSIONS: PMI seems common among patients undergoing LBBAP and may be associated with an increased risk of clinical outcomes in case of more pronounced (peak HsTnT &gt; fourfold the URL) myocardial damage occurring during the procedure.

Název v anglickém jazyce

Clinical impact and predictors of periprocedural myocardial injury among patients undergoing left bundle branch area pacing

Popis výsledku anglicky

BACKGROUND: The clinical impact of Periprocedural myocardial injury (PMI) in patients undergoing permanent pacemaker implantation with Left Bundle Branch Area Pacing (LBBAP) is unknown. METHODS: 130 patients undergoing LBBAP from January 2020 to June 2021 and completing 12 months follow up were enrolled to assess the impact of PMI on composite clinical outcome (CCO) defined as any of the following: all-cause death, hospitalization for heart failure (HHF), hospitalization for acute coronary syndrome (ACS) and ventricular arrhythmias (VAs). High sensitivity Troponin T (HsTnT) was measured up to 24-h after intervention to identify the peak HsTnT values. PMI was defined as increased peak HsTnT values at least &gt; 99th percentile of the upper reference limit (URL: 15 pg/ml) in patients with normal baseline values. RESULTS: PMI occurred in 72 of 130 patients (55%). ROC analysis yielded a post-procedural peak HsTnT cutoff of fourfold the URL for predicting the CCO (AUC: 0.692; p = 0.023; sensitivity 73% and specificity 71%). Of the enrolled patients, 20% (n = 26) had peak HsTnT &gt; fourfold the URL. Patients with peak HsTnT &gt; fourfold the URL exhibited a higher incidence of the CCO than patients with peak HsTnT &lt;= fourfold the URL (31% vs. 10%; p = 0.005), driven by more frequent hospitalizations for ACS (15% vs. 3%; p = 0.010). Multiple (&gt; 2) lead repositions attempts, the use of septography and stylet-driven leads were independent predictors of higher risk of PMI with peak HsTnT &gt; fourfold the URL. CONCLUSIONS: PMI seems common among patients undergoing LBBAP and may be associated with an increased risk of clinical outcomes in case of more pronounced (peak HsTnT &gt; fourfold the URL) myocardial damage occurring during the procedure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Interventional Cardiac Electrophysiology

ISSN

1383-875X

e-ISSN

1572-8595

Svazek periodika

67

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

12

Strana od-do

2039-2050

Kód UT WoS článku

001263317800001

EID výsledku v databázi Scopus

2-s2.0-85197729752