The interplay of mouse and porcine biomodels for endocrine disruptor reproductive impairment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10382896" target="_blank" >RIV/00216208:11140/18:10382896 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027014:_____/18:N0000269

Výsledek na webu

<a href="http://www.cvzv.sk/slju/18_4/SJAS_4_2018.pdf" target="_blank" >http://www.cvzv.sk/slju/18_4/SJAS_4_2018.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The interplay of mouse and porcine biomodels for endocrine disruptor reproductive impairment

Popis výsledku v původním jazyce

Individual mammalian organisms, used as a biomedical model, represent partial benefits and drawbacks for transfer of knowledge into human medicine. Whereas some models, such as rhesus monkey, are more similar to human, its usage is difficult and controversial. In contrast, well-designed combination of several mammalian models shows effective way how to verify a hypothesis and, based on conservativeness of observed phenomenon, implicate it into the human medicine. The aim of this overview is to compare individual mammalian biomodels, with respect to reproductive biology, elucidation of reproductive toxicology and, in particular, to an effect of endocrine disruptors. The literature search is supplemented with own experimental designs and observations obtained using mouse and porcine models. Our findings point out advantages of in vivo exposure of oocyte, sperm or embryos of outbred mice to endocrine disruptors followed by verification using porcine in vitro treatment of cumulus-oocyte complexes with identical endocrine disrupting compound. In summary, the association between in vivo and in vitro exposure suggests about highly-relevant and available model for testing of endocrine disruptors and risk assessment for human reproductive health.

Název v anglickém jazyce

The interplay of mouse and porcine biomodels for endocrine disruptor reproductive impairment

Popis výsledku anglicky

Individual mammalian organisms, used as a biomedical model, represent partial benefits and drawbacks for transfer of knowledge into human medicine. Whereas some models, such as rhesus monkey, are more similar to human, its usage is difficult and controversial. In contrast, well-designed combination of several mammalian models shows effective way how to verify a hypothesis and, based on conservativeness of observed phenomenon, implicate it into the human medicine. The aim of this overview is to compare individual mammalian biomodels, with respect to reproductive biology, elucidation of reproductive toxicology and, in particular, to an effect of endocrine disruptors. The literature search is supplemented with own experimental designs and observations obtained using mouse and porcine models. Our findings point out advantages of in vivo exposure of oocyte, sperm or embryos of outbred mice to endocrine disruptors followed by verification using porcine in vitro treatment of cumulus-oocyte complexes with identical endocrine disrupting compound. In summary, the association between in vivo and in vitro exposure suggests about highly-relevant and available model for testing of endocrine disruptors and risk assessment for human reproductive health.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Slovak Journal of Animal Science

ISSN

1337-9984

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

10

Strana od-do

161-170

Kód UT WoS článku

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EID výsledku v databázi Scopus

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