Hybrid Imaging PET/CT with Application of F-18-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F18%3A10386449" target="_blank" >RIV/00216208:11140/18:10386449 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00669806:_____/18:10386449

Výsledek na webu

<a href="https://doi.org/10.21873/anticanres.12708" target="_blank" >https://doi.org/10.21873/anticanres.12708</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21873/anticanres.12708" target="_blank" >10.21873/anticanres.12708</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hybrid Imaging PET/CT with Application of F-18-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy

Popis výsledku v původním jazyce

Aim: To introduce the possible benefits of the positron-emission tomography (PET)Icomputed tomography (CT) with F-18-3&apos;-deoxy-3&apos;-fluorothymidine ( F-18-FLT) in patients with orofacial carcinomas and its impact to patient management. Materials and Methods: Thirty-six patients with orofacial squamous cell carcinomas underwent F-18-FLT-PET/CT during radiotherapy. Examinations were performed after administration of F-18-FLT (1.8 MBq/kg) including full-diagnostic CT. Analysis of the radiotherapy effect was performed with possible prospect of repeated and focused irradiation. Results: Complete absence of F-18-FLT uptake was found in 20 patients, thus complete response to radiotherapy was reported. Persistence of focal F-18-FLT uptake was observed in 16 patients; in 11 patients, the measured activity was only mild. In five patients, a higher level of F-18-FLT uptake was measured and additional irradiation was performed in defined regions. Repeated follow-up proved complete regression F-18-FLT uptake. Conclusion: It was possible to assess the effect of radiotherapy with the use of F-18-FLT-PET/CT and findings are suitable for radiation dose-escalation planning.

Název v anglickém jazyce

Hybrid Imaging PET/CT with Application of F-18-Fluorothymidine in Patients with Head and Neck Carcinoma Undergoing Radiotherapy

Popis výsledku anglicky

Aim: To introduce the possible benefits of the positron-emission tomography (PET)Icomputed tomography (CT) with F-18-3&apos;-deoxy-3&apos;-fluorothymidine ( F-18-FLT) in patients with orofacial carcinomas and its impact to patient management. Materials and Methods: Thirty-six patients with orofacial squamous cell carcinomas underwent F-18-FLT-PET/CT during radiotherapy. Examinations were performed after administration of F-18-FLT (1.8 MBq/kg) including full-diagnostic CT. Analysis of the radiotherapy effect was performed with possible prospect of repeated and focused irradiation. Results: Complete absence of F-18-FLT uptake was found in 20 patients, thus complete response to radiotherapy was reported. Persistence of focal F-18-FLT uptake was observed in 16 patients; in 11 patients, the measured activity was only mild. In five patients, a higher level of F-18-FLT uptake was measured and additional irradiation was performed in defined regions. Repeated follow-up proved complete regression F-18-FLT uptake. Conclusion: It was possible to assess the effect of radiotherapy with the use of F-18-FLT-PET/CT and findings are suitable for radiation dose-escalation planning.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Anticancer Research

ISSN

0250-7005

e-ISSN

—

Svazek periodika

38

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

5

Strana od-do

4153-4157

Kód UT WoS článku

000449943500047

EID výsledku v databázi Scopus

2-s2.0-85049777681