Primary cutanous desmoplastic melanoma with collagen rosettes and pseudoglandular features
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F21%3A10427571" target="_blank" >RIV/00216208:11140/21:10427571 - isvavai.cz</a>
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YQZTjT3JEL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=YQZTjT3JEL</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/DAD.0000000000001809" target="_blank" >10.1097/DAD.0000000000001809</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Primary cutanous desmoplastic melanoma with collagen rosettes and pseudoglandular features
Popis výsledku v původním jazyce
Cutaneous desmoplastic melanoma (DM) is an uncommon variant of spindle cell melanoma accounting for less than 4% of primary melanomas of the skin. The most common clinical presentation is a firm nonpigmented nodule or plaque on severely sun-damaged skin of elderly male individuals.1 Histologically, DM is a heterogeneous group of melanocytic tumors phenotypically ranging from a scar-like paucicellular proliferation of bland fusiform melanocytes separated by a dense collagenous stroma to high-grade sarcoma-like pleomorphic spindled cells with a variable degree of stromal desmoplasia.2-7 An atypical junctional melanocytic proliferation in the overlying epidermis and lymphocytic aggregates at the periphery of the tumor are often a feature, representing useful diagnostic clues, although the so-called DM arising "de novo" lacks a junctional melanocytic component.8 Histopathological variations in DM include striking neurotropism with perineural and endoneurial invasion (neurotropic desmoplastic melanoma),9 prominent Schwannian and perineural features (neural transformation),10 marked myoid/myofibroblastic differentiation in the stroma, and others.11,12 Molecular analysis of DM reveals a high-mutation burden, ultraviolet (UV) signature, and frequent mutations in NF1 (55%), TP53 (48%), and CDKN2A (47%).13-16 In this article, we present a very unusual case of neurotropic DM with collagen rosette formation, clear cell change, epithelioid cells, and pseudoglandular features.
Název v anglickém jazyce
Primary cutanous desmoplastic melanoma with collagen rosettes and pseudoglandular features
Popis výsledku anglicky
Cutaneous desmoplastic melanoma (DM) is an uncommon variant of spindle cell melanoma accounting for less than 4% of primary melanomas of the skin. The most common clinical presentation is a firm nonpigmented nodule or plaque on severely sun-damaged skin of elderly male individuals.1 Histologically, DM is a heterogeneous group of melanocytic tumors phenotypically ranging from a scar-like paucicellular proliferation of bland fusiform melanocytes separated by a dense collagenous stroma to high-grade sarcoma-like pleomorphic spindled cells with a variable degree of stromal desmoplasia.2-7 An atypical junctional melanocytic proliferation in the overlying epidermis and lymphocytic aggregates at the periphery of the tumor are often a feature, representing useful diagnostic clues, although the so-called DM arising "de novo" lacks a junctional melanocytic component.8 Histopathological variations in DM include striking neurotropism with perineural and endoneurial invasion (neurotropic desmoplastic melanoma),9 prominent Schwannian and perineural features (neural transformation),10 marked myoid/myofibroblastic differentiation in the stroma, and others.11,12 Molecular analysis of DM reveals a high-mutation burden, ultraviolet (UV) signature, and frequent mutations in NF1 (55%), TP53 (48%), and CDKN2A (47%).13-16 In this article, we present a very unusual case of neurotropic DM with collagen rosette formation, clear cell change, epithelioid cells, and pseudoglandular features.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30109 - Pathology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
American Journal of Dermatopathology
ISSN
0193-1091
e-ISSN
—
Svazek periodika
43
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
4
Strana od-do
221-224
Kód UT WoS článku
000656633800015
EID výsledku v databázi Scopus
2-s2.0-85102211739